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大肠杆菌、鼠伤寒沙门氏菌和粘质沙雷氏菌dnaA核苷酸序列的比较。

Comparison of dnaA nucleotide sequences of Escherichia coli, Salmonella typhimurium, and Serratia marcescens.

作者信息

Skovgaard O, Hansen F G

出版信息

J Bacteriol. 1987 Sep;169(9):3976-81. doi: 10.1128/jb.169.9.3976-3981.1987.

DOI:10.1128/jb.169.9.3976-3981.1987
PMID:3040670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC213696/
Abstract

The dnaA genes of Salmonella typhimurium and Serratia marcescens, which complemented the temperature-sensitive dnaA46 mutation of Escherichia coli, were cloned and sequenced. They were very homologous to the dnaA gene of E. coli. The 63 N-terminal amino acids and the 333 C-terminal amino acids of the corresponding DnaA proteins were identical. The region in between, corresponding to 71 amino acids in E. coli, exhibited a number of changes. This variable region coincided with a nonhomologous region found in the comparison of E. coli dnaA and Bacillus subtilis "dnaA" genes. The regions upstream of the genes were also homologous. The ribosome-binding area, one of the promoters, the DnaA protein-binding site, and many GATC sites (Dam methyltransferase-recognition sequence) were conserved in these three enteric bacteria.

摘要

鼠伤寒沙门氏菌和粘质沙雷氏菌的dnaA基因可互补大肠杆菌温度敏感型dnaA46突变，对其进行了克隆和测序。它们与大肠杆菌的dnaA基因高度同源。相应DnaA蛋白的63个N端氨基酸和333个C端氨基酸相同。两者之间对应于大肠杆菌71个氨基酸的区域出现了一些变化。这个可变区域与大肠杆菌dnaA基因和枯草芽孢杆菌“dnaA”基因比较中发现的一个非同源区域重合。这些基因上游的区域也具有同源性。核糖体结合区域、其中一个启动子、DnaA蛋白结合位点以及许多GATC位点（Dam甲基转移酶识别序列）在这三种肠道细菌中保守。

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本文引用的文献

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The initiation of chromosome replication in a dnaAts46 and a dnaA+ strain at various temperatures.在不同温度下，dnaAts46菌株和dnaA+菌株中染色体复制的起始情况。
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