Oberto J, Rouviere-Yaniv J
Laboratoire de Physiologie Bactérienne, Institut de Biologie Physico-chimique, Paris, France.
J Bacteriol. 1996 Jan;178(1):293-7. doi: 10.1128/jb.178.1.293-297.1996.
Homologs of the dimeric HU protein of Escherichia coli can be found in every prokaryotic organism that has been analyzed. In this work, we demonstrate that Serratia marcescens synthesizes two distinct HU subunits, like E. coli and Salmonella typhimurium, suggesting that the heterodimeric HU protein could be a common feature of enteric bacteria. A phylogenetic analysis of the HU-type proteins (HU and IHF) is presented, and a scheme for the origin of the hup genes and the onset of HU heterodimericity is suggested.
在每一种经过分析的原核生物中都能找到大肠杆菌二聚体HU蛋白的同源物。在这项研究中,我们证明粘质沙雷氏菌像大肠杆菌和鼠伤寒沙门氏菌一样,能合成两种不同的HU亚基,这表明异源二聚体HU蛋白可能是肠道细菌的一个共同特征。本文对HU型蛋白(HU和IHF)进行了系统发育分析,并提出了hup基因的起源及HU异源二聚体形成起始的一种假说。