Department of Diabetes, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Department of Medicine and Surgery, University of Parma and Azienda Ospedaliera Universitaria di Parma, Parma, Italy.
J Clin Endocrinol Metab. 2019 Apr 1;104(4):1201-1210. doi: 10.1210/jc.2018-01809.
Intrapancreatic lipid (IPL) has been linked to β-cell dysfunction. Black populations disproportionately develop type 2 diabetes (T2D) and show distinctions in β-cell function compared with white populations.
We quantified IPL in white European (WE) and black West African (BWA) men with early T2D and investigated the relationships between IPL and β-cell insulin secretory function (ISF).
DESIGN, SETTING, AND PARTICIPANTS: We performed a cross-sectional assessment of 18 WE and 19 BWA middle-age men with early T2D as part of the South London Diabetes and Ethnicity Phenotyping study.
The participants underwent Dixon MRI to determine IPL in the pancreatic head, body, and tail and subcutaneous and visceral adipose tissue volumes. Modeled first- and second-phase ISFs were comprehensively determined using C-peptide measurements during a 3-hour meal tolerance test and a 2-hour hyperglycemic clamp test.
The WE men had greater mean IPL levels compared with BWA men (P = 0.029), mainly owing to greater IPL levels in the pancreatic head (P = 0.009). The mean IPL level was inversely associated with orally stimulated first-phase ISF in WE but not BWA men (WE, r = -0.554, P = 0.026; BWA, r = -0.183, P = 0.468). No association was found with orally stimulated second-phase ISF in either WE or BWA men. No associations were found between the mean IPL level and intravenously stimulated ISF.
The IPL levels were lower in BWA than WE men with early T2D, and the lack of inverse association with first-phase ISF in BWA men indicates that IPL might be a less important determinant of the development of T2D in BWA than in WE men.
胰内脂质（IPL）与β细胞功能障碍有关。黑人群体不成比例地发展为 2 型糖尿病（T2D），并且与白人群体相比，β细胞功能存在差异。
我们量化了患有早期 T2D 的白种欧洲人（WE）和黑种西非人（BWA）男性中的 IPL，并研究了 IPL 与β细胞胰岛素分泌功能（ISF）之间的关系。
设计、地点和参与者：我们对 18 名 WE 和 19 名 BWA 中年患有早期 T2D 的男性进行了横断面评估，作为南伦敦糖尿病和种族表型研究的一部分。
参与者接受了 Dixon MRI 检查，以确定胰头部、体部和尾部以及皮下和内脏脂肪组织体积中的 IPL。通过在 3 小时的口服耐量试验和 2 小时的高血糖钳夹试验中测量 C 肽来全面确定第一和第二阶段 ISF。
WE 男性的平均 IPL 水平高于 BWA 男性（P = 0.029），主要是由于胰头部的 IPL 水平较高（P = 0.009）。WE 男性的平均 IPL 水平与口服刺激的第一阶段 ISF 呈负相关，但 BWA 男性则无此相关性（WE，r = -0.554，P = 0.026；BWA，r = -0.183，P = 0.468）。在 WE 或 BWA 男性中，均未发现与口服刺激的第二阶段 ISF 相关。在 WE 或 BWA 男性中，平均 IPL 水平与静脉内刺激的 ISF 之间均无关联。
患有早期 T2D 的 BWA 男性的 IPL 水平低于 WE 男性，BWA 男性中 IPL 水平与第一阶段 ISF 之间缺乏负相关关系表明，与 WE 男性相比，在 BWA 男性中，IPL 可能不是 T2D 发展的一个重要决定因素。
