Diabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UK.
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH 03755-1404, USA.
Nutrients. 2020 Dec 11;12(12):3796. doi: 10.3390/nu12123796.
In this study, we aimed to assess ethnic differences in visceral (VAT), deep subcutaneous (dSAT), and superficial subcutaneous (sSAT) adipose tissue and their relationships with inflammatory markers between white European (WE) and black West African (BWA) men with normal glucose tolerance (NGT) and type 2 diabetes (T2D). Forty-two WE (23 NGT/19 T2D) and 43 BWA (23 NGT/20 T2D) men underwent assessment of plasma inflammatory markers using immunoassays alongside Dixon magnetic resonance imaging to quantify L4-5 VAT, dSAT and sSAT. Despite no ethnic differences in sSAT and dSAT, BWA men exhibited lower VAT ( = 0.002) and dSAT:sSAT ( = 0.047) than WE men. Adiponectin was inversely associated with sSAT in WE ( = 0.041) but positively associated in BWA ( = 0.031) men with T2D. Interleukin-6 (IL-6) was associated with VAT in WE but not in BWA men with NGT (WE: = 0.009, BWA: = 0.137) and T2D (WE: = 0.070, BWA: = 0.175). IL-6 was associated with dSAT in only WE men with NGT (WE: = 0.030, BWA: = 0.833). The only significant ethnicity interaction present was for the relationship between adiponectin and sSAT ( = 0.003). The favourable adipose tissue distribution and the weaker relationships between adiposity and inflammation in BWA men suggest that adipose tissue inflammation may play a lesser role in T2D in BWA than WE men.
在这项研究中，我们旨在评估白种欧洲人（WE）和黑西非人（BWA）男性中正常葡萄糖耐量（NGT）和 2 型糖尿病（T2D）之间内脏（VAT）、深皮下（dSAT）和浅皮下（sSAT）脂肪组织的种族差异及其与炎症标志物的关系。42 名 WE（23 名 NGT/19 名 T2D）和 43 名 BWA（23 名 NGT/20 名 T2D）男性接受了使用免疫测定法评估血浆炎症标志物的检查，并进行了 L4-5 VAT、dSAT 和 sSAT 的 Dixon 磁共振成像定量检查。尽管 sSAT 和 dSAT 没有种族差异，但 BWA 男性的 VAT（ = 0.002）和 dSAT:sSAT（ = 0.047）低于 WE 男性。脂联素与 WE 男性的 sSAT 呈负相关（ = 0.041），但与 BWA 男性的 sSAT 呈正相关（ = 0.031）。白细胞介素-6（IL-6）与 WE 男性的 VAT 相关，但与 NGT （WE： = 0.009，BWA： = 0.137）和 T2D（WE： = 0.070，BWA： = 0.175）男性的 BWA 无关。只有在 WE 男性的 NGT 中，IL-6 才与 dSAT 相关（WE： = 0.030，BWA： = 0.833）。唯一存在的显著种族相互作用是脂联素与 sSAT 之间的关系（ = 0.003）。BWA 男性的脂肪组织分布良好，肥胖与炎症之间的关系较弱，这表明与 WE 男性相比，BWA 男性的脂肪组织炎症在 T2D 中的作用可能较小。
