Sugawara Y, Tsuji I, Mizoue T, Inoue M, Sawada N, Matsuo K, Ito H, Naito M, Nagata C, Kitamura Y, Sadakane A, Tanaka K, Tamakoshi A, Tsugane S, Shimazu T
Department of Health Informatics and Public Health, Division of Epidemiology, Graduate School of Medicine, Tohoku University School of Public Health, Sendai, Japan.
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Jpn J Clin Oncol. 2019 Jan 1;49(1):77-86. doi: 10.1093/jjco/hyy158.
There is a body of evidence to suggest that cigarette smoking increases the risk of cervical cancer in women, but no study has examined the magnitude of the association in Japanese women. Here, we evaluated the association between cigarette smoking and the risk of cervical cancer in Japanese women based on a systematic review of epidemiological evidence.
Original data were obtained from a MEDLINE search using PubMed or from a search of the 'Ichushi' database, as well as by a manual search. Evaluation of associations was based on the strength of evidence and the magnitude of association, together with biological plausibility as evaluated previously by the International Agency for Research on Cancer. Meta-analysis of associations was also conducted to obtain a summarized overview of the data.
We identified two cohort studies and three case-control studies. All five studies had indicated strong positive associations between cigarette smoking and the risk of cervical cancer. Our summary estimate indicated that the relative risk (RR) for individuals who had ever-smoked relative to never-smokers was 2.03 (95% confidence interval: 1.49-2.57). Four studies had also demonstrated dose-response relationships between cigarette smoking and the risk of cervical cancer.
We conclude that there is convincing evidence that cigarette smoking increases the risk of cervical cancer among Japanese women.
有大量证据表明吸烟会增加女性患宫颈癌的风险，但尚无研究调查日本女性中这种关联的程度。在此，我们基于对流行病学证据的系统综述，评估了吸烟与日本女性患宫颈癌风险之间的关联。
原始数据通过使用PubMed在MEDLINE中检索、检索“一志集”数据库以及手动检索获得。关联评估基于证据强度、关联程度以及国际癌症研究机构先前评估的生物学合理性。还对关联进行了荟萃分析以获得数据的汇总概述。
我们确定了两项队列研究和三项病例对照研究。所有五项研究均表明吸烟与宫颈癌风险之间存在强正相关。我们的汇总估计表明，曾经吸烟的个体相对于从不吸烟者的相对风险（RR）为2.03（95%置信区间：1.49 - 2.57）。四项研究还证明了吸烟与宫颈癌风险之间的剂量反应关系。
我们得出结论，有令人信服的证据表明吸烟会增加日本女性患宫颈癌的风险。
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