Lüttges J, Kalbfleisch H, Prinz P
J Cancer Res Clin Oncol. 1987;113(5):481-7. doi: 10.1007/BF00390043.
Our study examined 166 patients with breast cancer with a mean age of 63 years. Each patient underwent mastectomy with the organ being investigated by histological giant sections and additional small sections from the nipple. Nipple involvement was found in 64 cases (38%). Multifocal carcinoma occurred in 76 patients. Further multicentric carcinomatous foci (36 cases) demonstrated a significant increase in affected nipples. Additional atypical ductal or lobular hyperplasia was observed in 53 cases and showed involvement in 34. Nine carcinomas of ductal origin were combined with lobular carcinoma in situ, all cases proved to have carcinomatous changes in the nipple. It is concluded that apart from the well-known influence of advanced tumor stages and tumor localization, nipple involvement correlates with multicentricity and multifocality of breast cancer as a disease of the whole organ.
我们的研究对166例平均年龄为63岁的乳腺癌患者进行了检查。每位患者均接受了乳房切除术，通过组织学巨检以及乳头的额外小切片对该器官进行研究。发现64例（38%）存在乳头受累情况。76例患者发生多灶性癌。另外的多中心癌灶（36例）显示受累乳头显著增多。53例观察到额外的非典型导管或小叶增生，其中34例显示有受累情况。9例导管源性癌合并原位小叶癌，所有病例均证实乳头有癌变。结论是，除了晚期肿瘤分期和肿瘤定位的已知影响外，乳头受累与作为全器官疾病的乳腺癌的多中心性和多灶性相关。
