卡拉奇一家三级护理医院中血液系统癌症患儿的肿瘤溶解综合征：经验总结
Tumour Lysis Syndrome in children with haematological cancers: Experience at a tertiary care hospital in Karachi.
作者信息
Saeed Farhan, Ali Mohammad Shahzad, Ashraf Muhammad Shamvil, Vadsaria Khadija, Siddiqui Durre-E-Fatima
机构信息
Pediatric Oncology Department, The Indus Hospital, Karachi-Pakistan.
Indus Hospital Research Center, The Indus Hospital, Karachi-Pakistan.
出版信息
J Pak Med Assoc. 2018 Nov;68(11):1625-1630.
OBJECTIVE
To determine the incidence of tumour lysis syndrome and to identify associated factors and mortality rate in paediatric haematological patients.
METHODS
The prospective study was conducted from April to September 2016 at Indus Children Cancer Hospital, Karachi, and collected data for all new paediatric oncology patients registered with diagnosis of haematological malignancies. Each patient was monitored for a period of three days before and seven days after the start of the treatment. SPSS 21 was used for data analysis.
RESULTS
of the 232 patients, 86(37.1%) developed laboratory tumour lysis syndrome and 35(40.7%) of these patients developed the spontaneous variety. Overall, 24 (10.3%) patients progressed to clinical syndrome with 12(50%) of them developing spontaneous clinical syndrome. Mortality occurred in 17 (7.3%) patients.
CONCLUSIONS
Despite preventive measures, tumour lysis syndrome remains an oncological emergency in children with haematological malignancies.
目的
确定小儿血液系统疾病患者肿瘤溶解综合征的发生率，识别相关因素及死亡率。
方法
2016年4月至9月在卡拉奇的印度河儿童癌症医院进行了这项前瞻性研究，收集了所有诊断为血液系统恶性肿瘤的新儿科肿瘤患者的数据。每位患者在治疗开始前3天和开始后7天进行监测。使用SPSS 21进行数据分析。
结果
在232例患者中，86例（37.1%）发生了实验室肿瘤溶解综合征，其中35例（40.7%）发生了自发性肿瘤溶解综合征。总体而言，24例（10.3%）患者进展为临床综合征，其中12例（50%）发生了自发性临床综合征。17例（7.3%）患者死亡。
结论
尽管采取了预防措施，肿瘤溶解综合征仍是小儿血液系统恶性肿瘤的一种肿瘤急症。
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