新生霉素和香豆霉素A1可抑制病毒复制以及潜伏感染小鼠三叉神经节中单纯疱疹病毒1型的再激活。
Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice.
作者信息
Spivack J G, O'Boyle D R, Fraser N W
出版信息
J Virol. 1987 Oct;61(10):3288-91. doi: 10.1128/JVI.61.10.3288-3291.1987.
Abstract
Herpes simplex virus type 1 was reactivated from the trigeminal ganglia of latently infected mice in a quantitative and time-dependent manner. Novobiocin and coumermycin A1 reversibly inhibited the reactivation of herpes simplex virus type 1. They did not inhibit viral replication in permissive cells (CV-1) but did inhibit replication in cells of neuronal origin (C1300) and acutely infected trigeminal ganglia.
摘要
1型单纯疱疹病毒从潜伏感染小鼠的三叉神经节中以定量和时间依赖性方式重新激活。新生霉素和香豆霉素A1可逆地抑制1型单纯疱疹病毒的重新激活。它们不抑制在允许性细胞（CV-1）中的病毒复制，但抑制在神经元来源的细胞（C1300）和急性感染的三叉神经节中的复制。
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