2,2'-O-环胞苷和阿昔洛韦对小鼠三叉神经节中潜伏单纯疱疹病毒的影响。
Effects of 2,2'-O-cyclocytidine and acyclovir on latent herpes simplex virus in trigeminal ganglia of mice.
作者信息
Liu W G, Chen Z J, Song J Z, Ma Z X
出版信息
Antimicrob Agents Chemother. 1986 Feb;29(2):278-80. doi: 10.1128/AAC.29.2.278.
The effects of 2,2'-O-cyclocytidine (CC) and acyclovir (ACV) on latent herpes simplex virus (HSV) in trigeminal ganglia were studied in an in vitro model using reactivation of HSV type 1 (HSV-1) as a model. It was shown that both CC (10 micrograms/ml) and ACV (2.5 micrograms/ml) significantly inhibited the reactivation of the latent HSV-1 in infected ganglia. The effect of CC (25 micrograms/ml), which was as good as that of ACV (10 micrograms/ml), did not last as long as that of ACV after removal of the drugs. The latent state of HSV-1 in vitro was dependent on the continuous presence of either drug. Even though the latent HSV-1 could not be eliminated completely from the trigeminal ganglia by discontinuous administration of either drug, its titers were markedly reduced. The combination of CC and ACV had a synergistic effect on preventing the reactivation of the latent HSV-1 in vitro.
在以1型单纯疱疹病毒（HSV-1）再激活为模型的体外模型中，研究了2,2'-O-环胞苷（CC）和阿昔洛韦（ACV）对三叉神经节中潜伏单纯疱疹病毒（HSV）的影响。结果表明，CC（10微克/毫升）和ACV（2.5微克/毫升）均能显著抑制感染神经节中潜伏HSV-1的再激活。CC（25微克/毫升）的效果与ACV（10微克/毫升）相当，但在去除药物后，其作用持续时间不如ACV长。体外HSV-1的潜伏状态依赖于两种药物中的任何一种持续存在。尽管通过间断给予任何一种药物都不能完全从三叉神经节中消除潜伏的HSV-1，但其滴度显著降低。CC和ACV联合使用对预防体外潜伏HSV-1的再激活具有协同作用。
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