（E）-5-（2-溴乙烯基）-2'-脱氧尿苷、5'-氨基-5-碘-2'，5'-二脱氧尿苷和2-脱氧-D-葡萄糖对潜伏性神经节单纯疱疹病毒感染的体外作用。

In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection.

作者信息

Pavan-Langston D, Park N H, De Clercq E

出版信息

Antiviral Res. 1984 Apr;4(1-2):53-61. doi: 10.1016/0166-3542(84)90025-1.

Abstract

(E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU) and 5'-amino-5-iodo-2',5'-dideoxy-uridine AIdUrd, blocked the reactivation of latent ganglionic herpes simplex virus in vitro. Furthermore, BVDU, but not AIdUrd, blocked the multiplication of reactivated latent virus and transiently suppressed emergence of reactivated virus from the sensory ganglia after removal of drug from the medium. 2-Deoxy-D-glucose (2-DG) neither prevented the in vitro reactivation of latent virus nor blocked the further multiplication of reactivated latent virus.

摘要

（E）-5-（2-溴乙烯基）-2'-脱氧尿苷（BVDU）和5'-氨基-5-碘-2'，5'-二脱氧尿苷（AIdUrd）在体外可阻断潜伏性神经节单纯疱疹病毒的复活。此外，BVDU可阻断复活的潜伏病毒的增殖，而AIdUrd则不能，并且在从培养基中去除药物后，BVDU可短暂抑制感觉神经节中复活病毒的出现。2-脱氧-D-葡萄糖（2-DG）既不能阻止潜伏病毒的体外复活，也不能阻断复活的潜伏病毒的进一步增殖。