Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 117004, PR China.
Pharmacy Department, Liaoning Cancer Hospital & Institue, Shenyang, Liaoning 110042, PR China.
Nanomedicine (Lond). 2018 Dec;13(24):3159-3177. doi: 10.2217/nnm-2018-0288. Epub 2018 Nov 9.
In traditional nano drug-delivery systems, the complex chemical bonds between drug and carrier often complicate the preparation process and are less prone to rupture upon entry into the target, which is detrimental to the timely release of the drug. The π-π stacking provides us with a promising alternative as it is a weak interaction between the aromatic rings. Since most antitumor drugs are hydrophobic molecules with complex aromatic π-π-conjugated structures, the construction of self-assembly based on π-π stacking between drugs and carriers has the advantage of improving the stability and drug loading capacity as well as the improvement of hydrophilicity and biosafety. This article introduces the recent advances in π-π stacking-guided nano self-assembly for antineoplastic delivery.
在传统的纳米药物传递系统中，药物与载体之间复杂的化学键往往使制备过程复杂化，并且在进入靶标时不易断裂，这不利于药物的及时释放。π-π 堆积为我们提供了一种有前途的替代方案，因为它是芳环之间的弱相互作用。由于大多数抗肿瘤药物是具有复杂芳环 π-π 共轭结构的疏水分子，因此基于药物与载体之间的 π-π 堆积构建自组装具有提高稳定性和载药量以及改善亲水性和生物安全性的优势。本文介绍了π-π 堆积引导的抗肿瘤递药纳米自组装的最新进展。
