Department of Medical Biology, Faculty of Medicine, Near East University, Nicosia, Cyprus; Research Center of Experimental Health Sciences (DESAM), Near East University, Nicosia, Cyprus.
Department of Histology and Embryology, Faculty of Medicine, Near East University, Nicosia, Cyprus.
Int J Biol Macromol. 2019 Feb 1;122:493-498. doi: 10.1016/j.ijbiomac.2018.10.059. Epub 2018 Oct 26.
Obesity, as a global health issue, is a complex metabolic syndrome and its association with many chronic diseases. The pathology of obesity results from an interaction of psychological, environmental and variety of genetic factors. Etiologic determinants and molecular pathophysiology of obesity have not yet understood clearly. Previously shown that genetic markers have a significant role in the development of obesity, although results are divergent with populations. Turkish Cypriots have a unique mixture of allele distributions as being a small-islander population. Therefore, the current study was aimed to evaluate the association between obesity and three putative obesity-related ADIPOQ, FTO and ACE gene markers, respectively. We investigated a possible association of ADIPOQ rs2241766 G>T, FTO rs9939609 A>T and ACE rs4340288 DIP variants among obese and non-obese Turkish Cypriot origin. Additionally, the correlation between these variants and biochemical and physical measurements were also evaluated to determine the possible biomarker for obesity in the population. Only FTO rs9939609 A>T polymorphism was associated with obesity and no association was observed with ADIPOQ rs2441666 G>T and ACE rs4340288 DIP. To conclude, FTO rs9939609 A allele found to have strong association with obesity in the population of Turkish Cypriots.
肥胖作为一个全球性的健康问题，是一种复杂的代谢综合征，与许多慢性疾病有关。肥胖的病理学是由心理、环境和多种遗传因素相互作用的结果。肥胖的病因和分子病理生理学尚未得到明确的理解。先前的研究表明，遗传标记物在肥胖的发展中起着重要作用，尽管结果在不同人群中存在分歧。土耳其塞浦路斯人作为一个小岛民群体，具有独特的等位基因分布混合。因此，本研究旨在评估肥胖与三个假定的肥胖相关的 ADIPOQ、FTO 和 ACE 基因标记之间的关联。我们研究了 ADIPOQ rs2241766 G>T、FTO rs9939609 A>T 和 ACE rs4340288 DIP 变异在肥胖和非肥胖的土耳其塞浦路斯人之间的可能关联。此外，还评估了这些变异与生化和物理测量之间的相关性，以确定该人群中肥胖的可能生物标志物。只有 FTO rs9939609 A>T 多态性与肥胖有关，而 ADIPOQ rs2441666 G>T 和 ACE rs4340288 DIP 与肥胖无关。总之，在土耳其塞浦路斯人人群中，发现 FTO rs9939609 A 等位基因与肥胖有很强的相关性。
