Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Department of Biological Sciences, Faculty of Science, Kuwait University, Safat, Kuwait.
Med Princ Pract. 2018;27(2):145-151. doi: 10.1159/000486767. Epub 2018 Jan 23.
To investigate the effect of the common fat mass and obesity-associated (FTO) gene polymorphism rs9939609 on body mass index (BMI) in one of the most obese populations worldwide.
Genotypic data for FTO rs9939609 were available for 1,034 unrelated Kuwaiti adults obtained from Kuwait's Dasman Diabetes Institute and Kuwait University. The association between the FTO polymorphism with BMI as continuous and categorical (normal BMI [< 25] vs. overweight/obese [> 25]) variables was analyzed using both linear and logistic regression models, respectively, with the assumption of both dominant and additive genetic models performed using the SNPassoc package from R statistics.
The A allele was associated with increased BMI (β = 1.21; 95% CI = 0.16-2.26; p = 0.023). In concordance, the categorical BMI (normal vs. overweight/obese) also showed a significant association between the A allele and overweight/obesity (OR = 1.47; 95% CI = 1.01-2.12; p = 0.041). However, no association between the FTO variant was observed with cardiometabolic traits.
We observed an association between the common FTO rs9939609 polymorphism and increased BMI (overweight/obesity) in Kuwaiti adults, which is consistent with previous research in other populations. Our findings encourage further investigation of genetic variants to elucidate the mechanisms involved in the development of obesity in such an obesogenic population.
研究常见肥胖相关基因（FTO）多态性 rs9939609 对全球最肥胖人群之一的体重指数（BMI）的影响。
从科威特 Dasman 糖尿病研究所和科威特大学获得了 1034 名无关科威特成年人的 FTO rs9939609 基因分型数据。使用线性和逻辑回归模型分别分析了 FTO 多态性与 BMI 连续和分类（正常 BMI [<25]与超重/肥胖 [>25]）变量之间的关联，假设显性和加性遗传模型使用 R 统计中的 SNPassoc 包执行。
A 等位基因与 BMI 增加相关（β=1.21；95%CI=0.16-2.26；p=0.023）。同样，分类 BMI（正常与超重/肥胖）也显示 A 等位基因与超重/肥胖之间存在显著关联（OR=1.47；95%CI=1.01-2.12；p=0.041）。然而，FTO 变体与心血管代谢特征之间没有关联。
我们观察到常见的 FTO rs9939609 多态性与科威特成年人 BMI（超重/肥胖）增加之间存在关联，这与其他人群的先前研究一致。我们的研究结果鼓励进一步研究遗传变异，以阐明在这种肥胖环境中肥胖发展所涉及的机制。
