Alothman Esraa A, Awaad Amani S, Safhi Amal A, Almoqren Shekhah S, El-Meligy Reham M, Zain Yara M, Alasmary Fatmah A, Alqasoumi Saleh I
Faculty of Pharmacy, Prince Sattam Bin Abdul-Aziz University, Saudi Arabia.
Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, Egypt.
Saudi Pharm J. 2018 Nov;26(7):956-959. doi: 10.1016/j.jsps.2018.05.004. Epub 2018 May 12.
L. was evaluated for its gastro antiulcerogenic and anti-ulcerative colitis activities Different extracts and fractions from aerial parts and roots were evaluated at different dose; total alcohol extracts of aerial parts SA and roots SR were evaluated doses 250 & 500 mg/kg, While Successive extracts (SAL, SRL, CSA, CSR, BSA & BSR) were evaluated at dose of 150 mg/kg. Absolute ethanol-induced ulcer model was used for evaluation of the anti-ulcerogenic activity. The root extract showed promising antiulcerogenic activity as the total alcohol extract of the root SR (500 mg/kg) produced 88.5% protection from control ulcer which is significantly more effective than the standard drug omeprazole (20 mg/kg), in addition, the butanol fraction of the root extract BSR also produced 76.66% protection from control ulcer. On the other hand, the aerial parts total extract SA showed low antiulcerogenic activity in both tested doses (250 & 500 mg/kg) as it produced 25% & 28.33% protection from control ulcer respectively. Only the butanol fraction of the aerial parts extract BSA showed promising activity 54.16%. In the acetic acid-induced ulcerative colitis model, among the investigated extracts of ; only the total extract of the aerial parts (SA) at dose 500 mg/kg showed strong anti-ulcerative colitis activity and this activity is followed by the activity of the butanol and chloroform fractions of the aerial parts, they produced 77.28%, 57.4% & 47.68% protection from control colitis respectively. The standard drug dexamethasone produced 63.36% protection from control colitis. The total alcohol extracts SR & SA showed no alteration on liver and kidney functions and these extracts are safe up to 5000 mg/kg. Phytochemical screening of the investigated extracts revealed the presence of carbohydrates, flavonoids, tannins, unsaturated sterols, proteins and lactones which could be responsible for the activities.
对L.进行了胃抗溃疡和抗溃疡性结肠炎活性评估。对地上部分和根部的不同提取物及馏分在不同剂量下进行了评估；地上部分SA和根部SR的总醇提取物在250和500mg/kg剂量下进行了评估，而连续提取物（SAL、SRL、CSA、CSR、BSA和BSR）在150mg/kg剂量下进行了评估。采用无水乙醇诱导的溃疡模型评估抗溃疡活性。根部提取物显示出有前景的抗溃疡活性，因为根部SR的总醇提取物（500mg/kg）对对照溃疡产生了88.5%的保护作用，这比标准药物奥美拉唑（20mg/kg）显著更有效。此外，根部提取物的丁醇馏分BSR对对照溃疡也产生了76.66%的保护作用。另一方面，地上部分总提取物SA在两个测试剂量（250和500mg/kg）下均显示出低抗溃疡活性，分别对对照溃疡产生了25%和28.33%的保护作用。只有地上部分提取物的丁醇馏分BSA显示出有前景的活性，为54.16%。在乙酸诱导的溃疡性结肠炎模型中，在所研究的提取物中，只有地上部分总提取物（SA）在500mg/kg剂量下显示出较强的抗溃疡性结肠炎活性，其次是地上部分的丁醇和氯仿馏分，它们分别对对照结肠炎产生了77.28%、57.4%和47.68%的保护作用。标准药物地塞米松对对照结肠炎产生了63.36%的保护作用。总醇提取物SR和SA对肝脏和肾脏功能无影响，这些提取物在高达5000mg/kg的剂量下是安全的。对所研究提取物的植物化学筛选揭示了碳水化合物、黄酮类化合物、单宁、不饱和甾醇、蛋白质和内酯的存在，这些可能是活性的原因。
