A stereoselective synthesis of (-)-tetrahydrolipstatin.
作者信息
Ghosh Arun K, Liu Chunfeng
机构信息
Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor Street, Chicago, Illinois 60607, USA.
出版信息
Chem Commun (Camb). 1999;1999(17):1743-1744. doi: 10.1039/A904533C.
Abstract
摘要
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RING-CLOSING METATHESIS STRATEGY TO UNSATURATED γ- AND δ-LACTONES: SYNTHESIS OF HYDROXYETHYLENE ISOSTERE FOR PROTEASE INHIBITORS.用于不饱和γ-和δ-内酯的关环复分解策略：蛋白酶抑制剂的羟乙烯等排体的合成。
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Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity.利普司他汀，一种由产毒链霉菌产生的胰脂肪酶抑制剂。I. 产生菌、发酵、分离及生物活性。
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Studies on the antiobesity activity of tetrahydrolipstatin, a potent and selective inhibitor of pancreatic lipase.
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Biochem J. 1988 Dec 1;256(2):357-61. doi: 10.1042/bj2560357.
6
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