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A stereoselective synthesis of (-)-tetrahydrolipstatin.

作者信息

Ghosh Arun K, Liu Chunfeng

机构信息

Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor Street, Chicago, Illinois 60607, USA.

出版信息

Chem Commun (Camb). 1999;1999(17):1743-1744. doi: 10.1039/A904533C.

DOI:10.1039/A904533C
PMID:30416366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6223123/
Abstract
摘要

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本文引用的文献

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RING-CLOSING METATHESIS STRATEGY TO UNSATURATED γ- AND δ-LACTONES: SYNTHESIS OF HYDROXYETHYLENE ISOSTERE FOR PROTEASE INHIBITORS.用于不饱和γ-和δ-内酯的关环复分解策略：蛋白酶抑制剂的羟乙烯等排体的合成。
Tetrahedron Lett. 1998 Jun 25;39(26):4651-4654. doi: 10.1016/S0040-4039(98)00887-9.
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First clinical studies with orlistat: a short review.奥利司他的首次临床研究：简要综述。
Obes Res. 1995 Nov;3 Suppl 4:623S-625S. doi: 10.1002/j.1550-8528.1995.tb00236.x.
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Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity.利普司他汀，一种由产毒链霉菌产生的胰脂肪酶抑制剂。I. 产生菌、发酵、分离及生物活性。
J Antibiot (Tokyo). 1987 Aug;40(8):1081-5. doi: 10.7164/antibiotics.40.1081.
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Studies on the antiobesity activity of tetrahydrolipstatin, a potent and selective inhibitor of pancreatic lipase.
Int J Obes. 1987;11 Suppl 3:35-42.
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Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin.共价抑制剂四氢脂抑素在体外对胰脂肪酶的抑制作用。
Biochem J. 1988 Dec 1;256(2):357-61. doi: 10.1042/bj2560357.
6
The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase.脂肪酶抑制剂四氢脂抑素与胰脂肪酶的假定活性位点丝氨酸共价结合。
J Biol Chem. 1991 Feb 5;266(4):2021-7.