• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The Mitochondrion: A Potential Therapeutic Target for Alzheimer's Disease.

作者信息

Lu Mei-Hong, Zhao Xiu-Yun, Yao Pei-Pei, Xu De-En, Ma Quan-Hong

机构信息

Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

出版信息

Neurosci Bull. 2018 Dec;34(6):1127-1130. doi: 10.1007/s12264-018-0310-y. Epub 2018 Nov 12.

DOI:10.1007/s12264-018-0310-y
PMID:30417261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6246833/
Abstract
摘要

相似文献

1
The Mitochondrion: A Potential Therapeutic Target for Alzheimer's Disease.线粒体：阿尔茨海默病的潜在治疗靶点。
Neurosci Bull. 2018 Dec;34(6):1127-1130. doi: 10.1007/s12264-018-0310-y. Epub 2018 Nov 12.
2
Synaptic Mitochondria: An Early Target of Amyloid-β and Tau in Alzheimer's Disease.突触线粒体：阿尔茨海默病中淀粉样β和tau 的早期靶标。
J Alzheimers Dis. 2021;84(4):1391-1414. doi: 10.3233/JAD-215139.
3
Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease.阿尔茨海默病中的异常tau、线粒体功能障碍、线粒体轴突运输受损和突触缺失。
Brain Res. 2011 Sep 30;1415:136-48. doi: 10.1016/j.brainres.2011.07.052. Epub 2011 Jul 31.
4
[Mitochondrial dysfunction and neuronal apoptosis: new molecular approach to prevent Alzheimer's disease].
Nihon Yakurigaku Zasshi. 2009 Oct;134(4):180-3. doi: 10.1254/fpj.134.180.
5
Mitochondrial Regulatory Pathways in the Pathogenesis of Alzheimer's Disease.阿尔茨海默病发病机制中的线粒体调控途径
J Alzheimers Dis. 2016 Jul 6;53(4):1257-70. doi: 10.3233/JAD-150967.
6
Recent Advances from the Bench Toward the Bedside in Alzheimer's Disease.阿尔茨海默病从实验室到临床的最新进展
EBioMedicine. 2015 Jan 9;2(2):94-5. doi: 10.1016/j.ebiom.2015.01.002. eCollection 2015 Feb.
7
Impaired transcription in Alzheimer's disease: key role in mitochondrial dysfunction and oxidative stress.阿尔茨海默病中的转录障碍：在线粒体功能障碍和氧化应激中的关键作用。
J Alzheimers Dis. 2013;34(1):115-31. doi: 10.3233/JAD-121444.
8
Alzheimer's pathogenesis and its link to the mitochondrion.阿尔茨海默病的发病机制及其与线粒体的联系。
Oxid Med Cell Longev. 2015;2015:803942. doi: 10.1155/2015/803942. Epub 2015 Apr 20.
9
Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease.体育锻炼与脑线粒体健康：对抗阿尔茨海默病的潜在作用
Brain Pathol. 2016 Sep;26(5):648-63. doi: 10.1111/bpa.12403.
10
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.分离于三月，共同起作用——磷酸化TAU在阿尔茨海默病线粒体功能障碍中的作用
Biochim Biophys Acta. 2014 Aug;1842(8):1258-66. doi: 10.1016/j.bbadis.2013.08.013. Epub 2013 Sep 17.

引用本文的文献

1
GPR50 regulates neuronal development as a mitophagy receptor.GPR50 作为一种线粒体自噬受体调节神经元发育。
Cell Death Dis. 2024 Aug 15;15(8):591. doi: 10.1038/s41419-024-06978-y.
2
Chronic Traumatic Encephalopathy as the Course of Alzheimer's Disease.慢性创伤性脑病作为阿尔茨海默病的病程。
Int J Mol Sci. 2024 Apr 24;25(9):4639. doi: 10.3390/ijms25094639.
3
Clarity on the blazing trail: clearing the way for amyloid-removing therapies for Alzheimer's disease.在探索的道路上拨云见日：为阿尔茨海默病的淀粉样蛋白清除疗法扫清障碍。
Mol Psychiatry. 2024 Feb;29(2):297-305. doi: 10.1038/s41380-023-02324-4. Epub 2023 Nov 24.
4
Mitochondrial Modulators: The Defender.线粒体调节剂：守护者。
Biomolecules. 2023 Jan 24;13(2):226. doi: 10.3390/biom13020226.
5
Prospective Evaluation of an Amide-Based Zinc Scaffold as an Anti-Alzheimer Agent: , , and Computational Studies.基于酰胺的锌支架作为抗阿尔茨海默病药物的前瞻性评估：实验、 及计算研究
ACS Omega. 2022 Jul 19;7(30):26723-26737. doi: 10.1021/acsomega.2c03058. eCollection 2022 Aug 2.
6
Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS.通过自噬减少导致的tau蛋白积累介导了肌萎缩侧索硬化症果蝇模型中GGGGCC重复序列扩增诱导的神经退行性变。
Neurosci Bull. 2020 Dec;36(12):1414-1428. doi: 10.1007/s12264-020-00518-2. Epub 2020 Jun 4.
7
Mitochondrial Dysfunction in Neural Injury.神经损伤中的线粒体功能障碍
Front Neurosci. 2019 Feb 4;13:30. doi: 10.3389/fnins.2019.00030. eCollection 2019.

本文引用的文献

1
Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer's disease as a mitophagy receptor.精神分裂症 1 区缺失蛋白作为一种线粒体自噬受体保护阿尔茨海默病转基因小鼠模型的突触可塑性。
Aging Cell. 2019 Feb;18(1):e12860. doi: 10.1111/acel.12860. Epub 2018 Nov 28.
2
Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease.阿尔茨海默病患者大脑中特定区域突触线粒体的耗竭。
Acta Neuropathol. 2018 Nov;136(5):747-757. doi: 10.1007/s00401-018-1903-2. Epub 2018 Sep 6.
3
NAD supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.NAD 补充使具有引入的 DNA 修复缺陷的新型 AD 小鼠模型中的关键阿尔茨海默病特征和 DNA 损伤反应正常化。
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. doi: 10.1073/pnas.1718819115. Epub 2018 Feb 5.
4
The Mitochondrial Basis of Aging and Age-Related Disorders.衰老及衰老相关疾病的线粒体基础
Genes (Basel). 2017 Dec 19;8(12):398. doi: 10.3390/genes8120398.
5
A Mouse Model of Alzheimer's Disease with Transplanted Stem-Cell-Derived Human Neurons.移植干细胞衍生的人类神经元的阿尔茨海默病小鼠模型
Neurosci Bull. 2017 Dec;33(6):766-768. doi: 10.1007/s12264-017-0180-8. Epub 2017 Sep 21.
6
Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease.海藻糖改善阿尔茨海默病转基因Tg2576小鼠模型的认知功能。
J Alzheimers Dis. 2017;60(2):549-560. doi: 10.3233/JAD-170322.
7
Attenuation of β-Amyloid Toxicity In Vitro and In Vivo by Accelerated Aggregation.通过加速聚集在体外和体内减轻β-淀粉样蛋白毒性
Neurosci Bull. 2017 Aug;33(4):405-412. doi: 10.1007/s12264-017-0144-z. Epub 2017 May 29.
8
Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.线粒体自噬与阿尔茨海默病：细胞和分子机制
Trends Neurosci. 2017 Mar;40(3):151-166. doi: 10.1016/j.tins.2017.01.002. Epub 2017 Feb 9.
9
Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death.烟酰胺单核苷酸可预防β-淀粉样寡聚体诱导的认知障碍和神经元死亡。
Brain Res. 2016 Jul 15;1643:1-9. doi: 10.1016/j.brainres.2016.04.060. Epub 2016 Apr 26.
10
Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins.人类野生型全长tau蛋白的积累通过增加线粒体融合蛋白来破坏线粒体动力学及其功能。
Sci Rep. 2016 Apr 21;6:24756. doi: 10.1038/srep24756.