Zhao Xiu-Yun, Lu Mei-Hong, Yuan De-Juan, Xu De-En, Yao Pei-Pei, Ji Wen-Li, Chen Hong, Liu Wen-Long, Yan Chen-Xiao, Xia Yi-Yuan, Li Shao, Tao Jin, Ma Quan-Hong
Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, China.
Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Front Neurosci. 2019 Feb 4;13:30. doi: 10.3389/fnins.2019.00030. eCollection 2019.
Mitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, and cell cycle. Mitochondrial dysfunction is observed in various neurological disorders which harbor acute and chronic neural injury such as neurodegenerative diseases and ischemia, hypoxia-induced brain injury. In this review, we describe how mitochondrial dysfunction contributes to the pathogenesis of neurological disorders which manifest chronic or acute neural injury.
线粒体是为细胞提供大部分能量的双层膜细胞器。此外，线粒体在各种细胞生物学过程中也发挥着重要作用，如钙信号传导、细胞凋亡、活性氧生成、细胞生长和细胞周期。在各种伴有急性和慢性神经损伤的神经疾病中都观察到线粒体功能障碍，如神经退行性疾病、缺血、缺氧性脑损伤。在这篇综述中，我们描述了线粒体功能障碍如何导致表现为慢性或急性神经损伤的神经疾病的发病机制。
