The Gastroenterology Department, Rabin Medical Center, Petach Tikva, Israel.
Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Cancer. 2019 Jan 1;125(1):118-126. doi: 10.1002/cncr.31764. Epub 2018 Nov 12.
There is growing concern regarding the impact of adolescent obesity on adult health. The objective of this study was to evaluate the association between body mass index (BMI) in late adolescence and the incidence of pancreatic cancer during adulthood.
The authors analyzed a cohort of 1087,358 Israeli Jewish men and 707,212 Jewish women who underwent a compulsory physical examination between ages 16 and 19 years from 1967 to 2002. Pancreatic cancer incidence through December 31, 2012 was identified by linkage to the national cancer registry. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for pancreatic cancer according to the US Centers for Disease Control and Prevention (CDC) BMI percentiles at baseline.
Over a median 23 year follow-up, 551 incident cases of pancreatic cancer cases occurred (423 men; 128 women). Compared with normal weight (5th to-<85th percentile), obesity (≥95th percentile) was associated with an increased risk of cancer among both men (HR, 3.67; 95% confidence interval [CI], 2.52-5.34) and women (HR, 4.07; 95% CI, 1.78-9.29). Among men, compared with low-normal BMI (≥5th to <25th percentile), high-normal BMI (≥75th to <85th percentile) and overweight (85th to 95th percentile) also were associated with a higher risk for cancer(high-normal BMI: HR, 1.49; 95% CI, 1.05-2.13; overweight: HR, 1.97; 95% CI, 1.39-2.80). The estimated population-attributable fraction because of overweight and obesity was 10.9% (95% CI, 6.1%-15.6%).
Men and women who were obese or overweight as adolescents are at an increased risk for subsequent pancreatic cancer.
青少年肥胖对成年健康的影响令人担忧。本研究的目的是评估青春期后期的体重指数（BMI）与成年后患胰腺癌的发生率之间的关系。
作者分析了 1967 年至 2002 年期间，1087358 名以色列犹太男性和 707212 名犹太女性在 16 至 19 岁之间接受的一次强制性体检队列。通过与国家癌症登记处的链接，确定截至 2012 年 12 月 31 日的胰腺癌发病情况。多变量调整后的 Cox 回归用于根据美国疾病控制与预防中心（CDC）的 BMI 百分位数，在基线时估计胰腺癌的风险比（HR）。
在中位数 23 年的随访期间，共发生 551 例胰腺癌病例（423 例男性；128 例女性）。与正常体重（第 5 至<85 百分位）相比，肥胖（≥95 百分位）与男性（HR，3.67；95%置信区间[CI]，2.52-5.34）和女性（HR，4.07；95%CI，1.78-9.29）的癌症风险增加有关。在男性中，与低正常 BMI（第 5 至<25 百分位）相比，高正常 BMI（第 75 至<85 百分位）和超重（85 至 95 百分位）也与癌症风险升高相关（高正常 BMI：HR，1.49；95%CI，1.05-2.13；超重：HR，1.97；95%CI，1.39-2.80）。超重和肥胖引起的人群归因分数为 10.9%（95%CI，6.1%-15.6%）。
青少年肥胖或超重的男性和女性患胰腺癌的风险增加。
