体力活动和健康与中年久坐成年人 S-Klotho 血浆水平的关系：FIT-AGEING 研究。
Association of physical activity and fitness with S-Klotho plasma levels in middle-aged sedentary adults: The FIT-AGEING study.
机构信息
EFFECTS-262 Research Group, Department of Medical Physiology, Faculty of Medicine, University of Granada, Spain; PROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Spain.
EFFECTS-262 Research Group, Department of Medical Physiology, Faculty of Medicine, University of Granada, Spain.
出版信息
Maturitas. 2019 May;123:25-31. doi: 10.1016/j.maturitas.2019.02.001. Epub 2019 Feb 5.
OBJECTIVES
To determine the association between physical activity and physical fitness levels (i.e. cardiorespiratory fitness and muscular strength) and the shed form of the α-Klotho gene (S-Klotho plasma levels) in middle-aged sedentary adults.
STUDY DESIGN AND MAIN OUTCOME MEASURES
A total of 74 middle-aged sedentary adults (52.7% women; 53.7 ± 5.1 years old) were enrolled in the FIT-AGEING study. Physical activity and sedentary time were assessed with a wrist-worn accelerometer. Maximal oxygen uptake (VOmax) was determined by a maximum treadmill test using indirect calorimetry. Lower- and upper-body muscular strength were assessed by an isokinetic strength test and by the hand grip strength test, respectively. The S-Klotho plasma levels were measured in the EDTA plasma using a solid-phase sandwich enzyme-linked immunosorbent assay.
RESULTS
Based on the principal-component analysis, overall physical activity, moderate and vigorous physical activity levels, and sedentary time (as outcomes included in the 'sedentary time and physical activity' category) explained a total of 17.5% of the cumulative variance in S-Klotho plasma levels, while extension peak torque, hand grip strength, and maximal oxygen uptake (as outcomes included in the 'physical fitness' category) explained a total of 15.5% of the cumulative variance in S-Klotho plasma levels. Based on the loading of variables in these 2 categories, the percentage of the cumulative variance in S-Klotho plasma level explained was 28.9%s; this reached 33.0% of cumulative variance when sex was included in the model.
CONCLUSIONS
In summary, our results indicate that physical activity and physical fitness levels are associated with S-Klotho plasma levels in middle-aged sedentary adults. Therefore, the S-Klotho protein could be a key factor in the relationship between physical activity and physical fitness and health improvements during the ageing process.
目的
确定身体活动和身体适应水平（即心肺适应能力和肌肉力量）与中年久坐成年人脱落形式的 α-Klotho 基因（S-Klotho 血浆水平）之间的关联。
研究设计和主要观察指标
共有 74 名中年久坐成年人（52.7%女性；53.7±5.1 岁）参加了 FIT-AGEING 研究。身体活动和久坐时间通过佩戴在手腕上的加速度计进行评估。最大摄氧量（VOmax）通过间接热量法的最大跑步机测试确定。下肢和上肢肌肉力量分别通过等速力量测试和手握力测试进行评估。S-Klotho 血浆水平通过固相夹心酶联免疫吸附试验在 EDTA 血浆中测量。
结果
基于主成分分析，总身体活动、中高强度身体活动水平和久坐时间（作为“久坐时间和身体活动”类别中的结果）共解释了 S-Klotho 血浆水平总变异的 17.5%，而伸展峰扭矩、手握力和最大摄氧量（作为“身体适应水平”类别中的结果）共解释了 S-Klotho 血浆水平总变异的 15.5%。基于这两个类别的变量负荷，S-Klotho 血浆水平总变异的解释百分比为 28.9%；当将性别纳入模型时，这一比例达到了总变异的 33.0%。
结论
总之，我们的结果表明，身体活动和身体适应水平与中年久坐成年人的 S-Klotho 血浆水平相关。因此，S-Klotho 蛋白可能是身体活动和身体适应水平与衰老过程中健康改善之间关系的关键因素。
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