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紫没食子素可保护角质形成细胞免受紫外线B辐射和细颗粒物2.5诱导的损伤和凋亡。

Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5.

作者信息

Zhen Ao Xuan, Piao Mei Jing, Hyun Yu Jae, Kang Kyoung Ah, Ryu Yea Seong, Cho Suk Ju, Kang Hee Kyoung, Koh Young Sang, Ahn Mee Jung, Kim Tae Hoon, Hyun Jin Won

机构信息

Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea.

Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea.

出版信息

Biomol Ther (Seoul). 2019 Jul 1;27(4):395-403. doi: 10.4062/biomolther.2018.151.

DOI:10.4062/biomolther.2018.151
PMID:30419635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6609104/
Abstract

Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and PM severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or PM. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and PM.

摘要

紫铆因是一种从橡木五倍子中提取的天然酚类物质，已被证明具有抗氧化、抗癌和抗炎作用。最近，除了通过氧化应激诱导细胞凋亡的紫外线B（UVB）辐射外，细颗粒物2.5（PM）也被证明会引发活性氧的过量产生。在本研究中，我们观察到UVB辐射和PM严重损伤了人HaCaT角质形成细胞，破坏了细胞DNA、脂质和蛋白质，并导致线粒体去极化。紫铆因保护HaCaT细胞免受UVB辐射和/或PM诱导的凋亡。此外，紫铆因通过半胱天冬酶信号通路有效地调节UVB照射下的促凋亡和抗凋亡蛋白。此外，如使用MAPK-p38、ERK和JNK抑制剂所证明的，紫铆因通过MAPK信号通路减少凋亡。这些结果表明，紫铆因具有抗氧化作用，并保护细胞免受UVB辐射和PM诱导的损伤和凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f7/6609104/2bf003c89f56/bt-27-395f7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f7/6609104/2bf003c89f56/bt-27-395f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f7/6609104/83cbb5d2891a/bt-27-395f1.jpg
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