Department of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Department of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Reprod Biomed Online. 2018 Dec;37(6):725-731. doi: 10.1016/j.rbmo.2018.09.017. Epub 2018 Oct 26.
What are the reproductive and obstetric outcomes of the gestational surrogacy treatment in the Netherlands?
This retrospective cohort study reports all data of gestational surrogacy treatment in the VU University Medical Centre over a period of 10 years. Data was collected from 60 intended parents and 63 gestational carriers, including reproductive and obstetric outcomes.
All intended mothers had a medical indication for gestational surrogacy and used autologous oocytes, and semen of the intended father. Ninety-three IVF cycles were initiated in 60 intended mothers, with subsequent 184 single embryo transfers in 63 gestational carriers. This resulted in 35 ongoing singleton pregnancies. At least one live birth was achieved for 55.0% of intended couples. Pregnancy was complicated in 20.6% by a hypertensive disorder. Labour was induced in 52.9%, and the Caesarean section rate was 8.8%. None of the pregnancies was complicated by preterm birth. Postpartum haemorrhage (>500 ml) occurred in 23.5%.
This study shows the effective results of the non-commercial gestational surrogacy programme in the Netherlands, in a multidisciplinary team setting. An increased risk for adverse obstetric outcomes in surrogate mothers is noted for hypertensive disorders and post-partum haemorrhage compared with the incidence in non-surrogacy pregnancies.
荷兰的妊娠代孕治疗的生殖和产科结局如何？
本回顾性队列研究报告了在 VU 大学医学中心进行的妊娠代孕治疗的所有数据，时间跨度为 10 年。数据来自 60 对有意向的父母和 63 名代孕母亲，包括生殖和产科结局。
所有意向母亲都有妊娠代孕的医学指征，并使用了自体卵子和意向父亲的精子。60 名意向母亲进行了 93 个试管婴儿周期，随后 63 名代孕母亲进行了 184 次单胚胎移植，导致 35 次单胎妊娠持续。55.0%的意向夫妇至少有一次活产。20.6%的妊娠出现高血压疾病并发症。52.9%的产妇进行了引产，剖宫产率为 8.8%。没有一例妊娠出现早产并发症。23.5%的产妇出现产后出血（>500ml）。
本研究展示了荷兰多学科团队中非商业性妊娠代孕项目的有效成果。与非代孕妊娠相比，代孕母亲出现高血压疾病和产后出血的不良产科结局的风险增加。
