高剂量头孢唑林可充分扩散至脑脊液，从而治疗与脑室外引流相关的脑室炎。
High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related Ventriculitis.
机构信息
Clinical Pharmacology Department, CHU Nantes, Nantes, France
UMR Inserm 1235 The Enteric Nervous System in Gut and Brain Disorders, University of Nantes, Nantes, France.
出版信息
Antimicrob Agents Chemother. 2019 Jan 29;63(2). doi: 10.1128/AAC.01844-18. Print 2019 Feb.
Abstract
A patient received continuous infusion of cefazolin 10 g then 8 g daily for an external ventricular drainage-related methicillin-susceptible (MSSA) ventriculitis. Median free concentrations in the cerebrospinal fluid were 11.9 and 6.1 mg/liter after 10- and 8-g doses, respectively. Free concentrations in the cerebrospinal fluid were always above the MIC usually displayed by methicillin-susceptible (MSSA) isolates. These results support the use of high-dose cefazolin to achieve sufficient meningeal concentrations.
摘要
一位患者因与外部脑室引流相关的耐甲氧西林金黄色葡萄球菌（MSSA）脑室炎而每天接受 10g 然后是 8g 的头孢唑啉连续输注。在 10g 和 8g 剂量后，脑脊液中的游离浓度中位数分别为 11.9 和 6.1mg/l。脑脊液中的游离浓度始终高于通常由耐甲氧西林金黄色葡萄球菌（MSSA）分离株显示的 MIC。这些结果支持使用高剂量头孢唑啉来达到足够的脑膜浓度。
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