College of Medicine, Seoul National University Bundang Hospital, Seoul National University, Gyeonggi, Korea.
Exp Dermatol. 2019 Jun;28(6):704-708. doi: 10.1111/exd.13844. Epub 2018 Dec 21.
Management of melasma is highly challenging due to inconsistent treatment results and frequent relapses. However, recent studies revealed that melasma may not only be a disease of melanocytes, but also a photoaging skin disorder. Herein, we attempt to validate that melasma is indeed a photoaging disorder by presenting the histopathologic findings of melasma: solar elastosis, altered basement membrane, increased vascularization and increased mast cell count. We also provide some therapeutic implications based on these findings and a discussion on the latest updates and perspectives regarding treatment.
由于治疗结果不一致和频繁复发，黄褐斑的管理极具挑战性。然而，最近的研究表明，黄褐斑可能不仅是黑素细胞疾病，还是一种光老化皮肤疾病。在此，我们试图通过展示黄褐斑的组织病理学发现来验证其确实是一种光老化疾病：日光弹性纤维变性、基底膜改变、血管化增加和肥大细胞计数增加。我们还根据这些发现提供了一些治疗意义，并讨论了最新的治疗更新和观点。
