Xiao Yao, Shi Kun, Qu Ying, Chu Bingyang, Qian Zhiyong
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu, China.
Mol Ther Methods Clin Dev. 2018 Sep 22;12:1-18. doi: 10.1016/j.omtm.2018.09.002. eCollection 2019 Mar 15.
In the past 10 years, with the increase of investment in clinical nano-gene therapy, there are many trials that have been discontinued due to poor efficacy and serious side effects. Therefore, it is particularly important to design a suitable gene delivery system. In this paper, we introduce the application of liposomes, polymers, and inorganics in gene delivery; also, different modifications with some stimuli-responsive systems can effectively improve the efficiency of gene delivery and reduce cytotoxicity and other side effects. Besides, the co-delivery of chemotherapy drugs with a drug tolerance-related gene or oncogene provides a better theoretical basis for clinical cancer gene therapy.
在过去的10年里，随着临床纳米基因治疗投资的增加，有许多试验因疗效不佳和严重副作用而停止。因此，设计合适的基因递送系统尤为重要。在本文中，我们介绍了脂质体、聚合物和无机物在基因递送中的应用；此外，一些刺激响应系统的不同修饰可以有效提高基因递送效率，降低细胞毒性和其他副作用。此外，化疗药物与耐药相关基因或癌基因的共递送为临床癌症基因治疗提供了更好的理论基础。
