Lee Jeong Woo, Park Min Gu, Cho Sung Yong
Department of Urology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, 27, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-773, Republic of Korea.
Department of Urology, Seoul Paik Hospital, Inje University College of Medicine, 9, Mareunnae-ro, Jung-gu, Seoul, 100-032, Republic of Korea.
BMC Urol. 2018 Nov 13;18(1):103. doi: 10.1186/s12894-018-0417-5.
To determine the most efficacious setting of Holmium:yttrium-aluminum-garnet (Ho:YAG) laser with a maximum power output of 120 W with in vitro phantom-stone dusting technique.
A laser was used to treat two 4 × 3 × 3 mm sized phantom stones in 5 mL syringes with 1 mm-sized holes at the bottom. According to the pulse width (short 500, middle 750, long pulse 1000 μsec), maximal pulse repetition rates from 50 to 80 Hz were tested with pulse energy of 0.2, 0.4, 0.5, and 0.8 J. Six times of the mean dusting times were measured at each setting. Dusting was performed at continuous firing of the laser until the stones become dusts < 1 mm.
The mean Hounsfield unit of phantom stones was 1309.0 ± 60.8. The laser with long pulse generally showed shorter dusting times than short or middle pulse width. With increasing the pulse energy to 0.5 J, the dusting time decreased. However, the pulse energy of 0.8 J showed longer dusting times than those of 0.5 J. On the post-hoc analysis, the pulse energy of 0.5 J, long pulse width, and the repetition rates of 70 Hz demonstrated significantly shorter dusting times than other settings.
The results suggest that long pulse width with 0.5 J and 70 Hz would be the most efficacious setting for dusting techniques of plaster stone phantoms simulating calcium oxalate stones using the 120 W Ho:YAG laser.
采用体外模拟结石粉尘化技术,确定最大功率输出为120W的钬激光(Ho:YAG)最有效的设置参数。
使用激光处理两个置于5mL注射器中的4×3×3mm大小的模拟结石,注射器底部有1mm大小的孔。根据脉冲宽度(短脉冲500μsec、中脉冲750μsec、长脉冲1000μsec),在脉冲能量为0.2、0.4、0.5和0.8J的情况下,测试50至80Hz的最大脉冲重复频率。在每个设置参数下测量六次平均粉尘化时间。持续发射激光进行粉尘化操作,直至结石变成小于1mm的粉尘。
模拟结石的平均亨氏单位为1309.0±60.8。长脉冲激光通常比短脉冲或中脉冲宽度的激光显示出更短的粉尘化时间。随着脉冲能量增加到0.5J,粉尘化时间缩短。然而,0.8J的脉冲能量显示出比0.5J更长的粉尘化时间。事后分析显示,0.5J的脉冲能量、长脉冲宽度和70Hz的重复频率的粉尘化时间明显短于其他设置参数。
结果表明,对于使用120W Ho:YAG激光模拟草酸钙结石的石膏结石模型的粉尘化技术,0.5J、长脉冲宽度和70Hz将是最有效的设置参数。