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中国的再生障碍性贫血

Aplastic Anemia in China.

作者信息

Liu Chunyan, Shao Zonghong

机构信息

Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.

出版信息

J Transl Int Med. 2018 Oct 9;6(3):134-137. doi: 10.2478/jtim-2018-0028. eCollection 2018 Sep.

DOI:10.2478/jtim-2018-0028
PMID:30425949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6231301/
Abstract

Aplastic anemia (AA) is a hematologic disease characterized by pancytopenia. Up to now, severe aplastic anemia (SAA) has been recognized by international and domestic scholars as an autoimmune disease with bone marrow (BM) failure mediated by the hyperfunctional T lymphocytes. The incidence of AA is more in China compared with other countries. In the recent years, both the pathogenesis and treatment of AA have made a great progress in our country. Thus, the therapeutic effect of AA was much better than before. Here, we conclude the researches of AA in China.

摘要

再生障碍性贫血(AA)是一种以全血细胞减少为特征的血液系统疾病。迄今为止,重型再生障碍性贫血(SAA)已被国际和国内学者公认为是一种由功能亢进的T淋巴细胞介导的骨髓衰竭的自身免疫性疾病。与其他国家相比,AA在中国的发病率更高。近年来,我国在AA的发病机制和治疗方面均取得了很大进展。因此,AA的治疗效果比以前要好得多。在此,我们总结了国内关于AA的研究。

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1
Aplastic Anemia in China.中国的再生障碍性贫血
J Transl Int Med. 2018 Oct 9;6(3):134-137. doi: 10.2478/jtim-2018-0028. eCollection 2018 Sep.
2
The Progress of Traditional Chinese Medicine in the Treatment of Aplastic Anemia.中医药治疗再生障碍性贫血的研究进展
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3
Special Education: Aplastic Anemia.特殊教育:再生障碍性贫血。
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4
[The significance of hematopoietic cell genetic instability in aplastic anemia.].
Zhonghua Xue Ye Xue Za Zhi. 2010 Apr;31(4):219-22.
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Evaluating and monitoring bone marrow hypoplasia in adults with aplastic anemia via high-resolution iliac magnetic resonance imaging in the current era.在当前时代,通过高分辨率髂骨磁共振成像评估和监测成人再生障碍性贫血患者的骨髓增生低下情况。
Medicine (Baltimore). 2019 Dec;98(49):e18214. doi: 10.1097/MD.0000000000018214.
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Idiopathic aplastic anemia: diagnosis and classification.特发性再生障碍性贫血:诊断和分类。
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Myelodysplastic syndrome and aplastic anemia: distinct entities or diseases linked by a common pathophysiology?骨髓增生异常综合征和再生障碍性贫血:不同的实体还是由共同病理生理学联系起来的疾病?
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Increased bone marrow (BM) plasma level of soluble CD30 and correlations with BM plasma level of interferon (IFN)-γ, CD4/CD8 T-cell ratio and disease severity in aplastic anemia.再生障碍性贫血患者骨髓血浆中可溶性CD30水平升高及其与骨髓血浆中干扰素(IFN)-γ水平、CD4/CD8 T细胞比值和疾病严重程度的相关性
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Recombinant human thrombopoietin improves hematopoietic stem cell differentiation and T-cell immune homeostasis in patients with severe aplastic anemia by upregulating c-MPL.重组人血小板生成素通过上调c-MPL改善重型再生障碍性贫血患者的造血干细胞分化和T细胞免疫稳态。
Front Pharmacol. 2025 Aug 25;16:1542837. doi: 10.3389/fphar.2025.1542837. eCollection 2025.
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Complex association of mean corpuscular volume and outcomes in patients with aplastic anemia treated with cyclosporine A plus androgen or cyclosporine A alone.再生障碍性贫血患者接受环孢素A加雄激素或单用环孢素A治疗时平均红细胞体积与预后的复杂关联。
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Heterogeneity in Health-Related Quality of Life of Patients with Aplastic Anemia: A Latent Profile Analysis.再生障碍性贫血患者健康相关生活质量的异质性:一项潜在剖面分析
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Aberrant myelomonocytic CD56 expression predicts response to cyclosporine therapy in pediatric patients with moderate aplastic anemia.异常的髓单核细胞CD56表达可预测中度再生障碍性贫血患儿对环孢素治疗的反应。
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本文引用的文献

1
[Clinical analysis on malignant clonal hematopoiesis in severe aplastic anemia patients with immunosuppressive therapy].[免疫抑制治疗的重型再生障碍性贫血患者恶性克隆造血的临床分析]
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[The current status and development of haploidentical allogeneic hematopoietic stem cell transplantation for severe aplastic anemia].[单倍体相合异基因造血干细胞移植治疗重型再生障碍性贫血的现状与进展]
Zhonghua Xue Ye Xue Za Zhi. 2015 Aug;36(8):707-10. doi: 10.3760/cma.j.issn.0253-2727.2015.08.019.
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Recombinant human thrombopoietin treatment promotes hematopoiesis recovery in patients with severe aplastic anemia receiving immunosuppressive therapy.重组人血小板生成素治疗可促进接受免疫抑制治疗的重型再生障碍性贫血患者的造血恢复。
Biomed Res Int. 2015;2015:597293. doi: 10.1155/2015/597293. Epub 2015 Mar 11.
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IgG autoantibody subclasses altered in immuno-related hemocytopenia.免疫相关血细胞减少症中发生改变的IgG自身抗体亚类
Cell Immunol. 2015 Mar;294(1):13-20. doi: 10.1016/j.cellimm.2015.01.013. Epub 2015 Jan 31.
6
Porcine antilymphocyte globulin (p-ALG) plus cyclosporine A (CsA) treatment in acquired severe aplastic anemia: a retrospective multicenter analysis.猪抗淋巴细胞球蛋白(p-ALG)联合环孢素A(CsA)治疗获得性重型再生障碍性贫血:一项回顾性多中心分析。
Ann Hematol. 2015 Jun;94(6):955-62. doi: 10.1007/s00277-015-2308-0. Epub 2015 Feb 11.
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Fas/FasL in the immune pathogenesis of severe aplastic anemia.Fas/FasL在重型再生障碍性贫血免疫发病机制中的作用
Genet Mol Res. 2014 May 30;13(2):4083-8. doi: 10.4238/2014.May.30.3.
8
Expression of Shelterin component POT1 is associated with decreased telomere length and immunity condition in humans with severe aplastic anemia.Shelterin 组件 POT1 的表达与严重再生障碍性贫血患者端粒长度缩短和免疫状况有关。
J Immunol Res. 2014;2014:439530. doi: 10.1155/2014/439530. Epub 2014 May 6.
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Abnormalities of quantities and functions of linker for activations of T cells in severe aplastic anemia.重型再生障碍性贫血中T细胞激活连接蛋白的数量及功能异常
Eur J Haematol. 2014 Sep;93(3):214-23. doi: 10.1111/ejh.12327. Epub 2014 May 12.
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Granulocyte transfusion combined with granulocyte colony stimulating factor in severe infection patients with severe aplastic anemia: a single center experience from China.粒细胞输注联合粒细胞集落刺激因子治疗重型再生障碍性贫血合并严重感染患者:来自中国的单中心经验
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