Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Contact Dermatitis. 2019 Feb;80(2):110-113. doi: 10.1111/cod.13151. Epub 2018 Nov 13.
There was a global epidemic of methylchloroisothiazolinone (MCI) and/or methylisothiazolinone (MI) contact allergy from 2009 to 2015. In response, the Thai Ministry of Public Health regulated the use of MCI/MI in cosmetics.
To survey the presence of MCI/MI and MI alone, as labelled on cosmetics sold on the Thai market, before and after the ministerial directive.
The presence of MCI and/or MI in leave-on and rinse-off cosmetics sold on the market, based on the labelling of ingredients in 3445 products, was analysed.
Before the implementation date, most leave-on products contained MCI/MI. After the regulations came into force, the only leave-on cosmetic subcategories that complied with the law were facial skin-care, sunscreen and make-up products. MCI/MI and MI alone were found on the labels of both leave-on and rinse-off products, the presence of each varying between product subcategories.
Despite the ministerial regulations restricting their use, MCI and/or MI are still found in cosmetics sold on the Thai market. Dermatologists should be aware of this situation, and counsel patients to avoid products containing MCI and/or MI.
2009 年至 2015 年，甲基氯异噻唑啉酮（MCI）和/或甲基异噻唑啉酮（MI）接触过敏在全球范围内流行。作为回应，泰国公共卫生部规定了化妆品中 MCI/MI 的使用。
调查 MCI/MI 和 MI 单独作为标签出现在泰国市场销售的化妆品中的存在情况，分别在部令发布之前和之后进行。
根据 3445 种产品的成分标签，分析了市场上销售的留用型和冲洗型化妆品中 MCI 和/或 MI 的存在情况。
在实施日期之前，大多数留用型产品都含有 MCI/MI。法规生效后，唯一符合法律规定的留用型化妆品子类是面部护肤品、防晒霜和彩妆产品。MCI/MI 和 MI 单独出现在留用型和冲洗型产品的标签上，每种产品的存在情况因产品子类而异。
尽管部令限制了它们的使用，但 MCI 和/或 MI 仍存在于在泰国市场上销售的化妆品中。皮肤科医生应该了解这种情况，并建议患者避免使用含有 MCI 和/或 MI 的产品。
