Department of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Virginia Tech Carilion School of Medicine, 1906 Belleview Ave Roanoke VA, 24014, United States.
Department of Basic Science Education, Virginia Tech Carilion School of Medicine, 2 Riverside Circle Roanoke, VA, 24016, United States.
Lung Cancer. 2018 Nov;125:100-102. doi: 10.1016/j.lungcan.2018.09.009. Epub 2018 Sep 14.
Hyalinizing clear cell carcinomas (HCCC), now referred to as clear cell carcinomas (CCC) by the World Health Organization (WHO), are rare tumors usually arising from the salivary glands of the head and neck. We present the first case of a CCC originating from the trachea. A 66 year-old woman with history of hypertension, former smoker, presented to the emergency department reporting worsening shortness of breath. Computed chest tomography revealed a polypoid mass arising from the left posterior-lateral wall of the trachea. The patient developed worsening respiratory failure requiring mechanical ventilation. Bronchoscopy was completed which relieved a malignant airway obstruction and pathology revealed nests of cells with monomorphic nuclei and clear cytoplasm set in a hyalinized stroma. Using break apart probe fluorescence in situ hybridization testing the tissue revealed the presence of a recurring translocation of the Ewing sarcoma (EWSR1) gene, confirming the diagnosis. CCC is a rare primary airway tumor. CCC was first reported to originate in the lung in 2015. We present the first case of CCC arising from the trachea.
透明细胞癌（Hyalinizing clear cell carcinomas，HCCC），现被世界卫生组织（WHO）称为透明细胞癌（Clear cell carcinomas，CCC），是一种罕见的肿瘤，通常发生在头颈部的唾液腺。我们报告首例起源于气管的 CCC。一名 66 岁女性，有高血压病史，曾吸烟，因呼吸困难加重就诊于急诊。胸部计算机断层扫描显示一个源自气管左后外侧壁的息肉样肿块。患者呼吸衰竭恶化，需要机械通气。完成支气管镜检查缓解了恶性气道阻塞，病理显示细胞巢具有单一形态核和透明细胞质，位于玻璃样基质中。使用分离探针荧光原位杂交检测组织显示存在尤文肉瘤（Ewing sarcoma，EWSR1）基因的重现性易位，从而确诊。CCC 是一种罕见的原发性气道肿瘤。2015 年首次报道 CCC 起源于肺部。我们报告首例起源于气管的 CCC。
