原发性肺透明细胞黏液样癌：活检诊断的挑战。
Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy.
机构信息
Department of Oncology, Anhui Wanbei Coal-Electricity Group General Hospital, Suzhou, China.
Department of Pathology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, China.
出版信息
Diagn Pathol. 2022 Mar 27;17(1):35. doi: 10.1186/s13000-022-01216-5.
INTRODUCTION
Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors. They most commonly involve the minor salivary glands of the head and neck. HCCC that occurs in uncommon locations and examining samples from small biopsy pose a diagnostic challenge for most pathologists.
CASE PRESENTATION
We herein report a primary pulmonary HCCC diagnosed by small biopsy and summarize its histologic, immunophenotypic, and molecular features along with a review of 11 previously reported cases to emphasize the potential diagnostic pitfalls.
CONCLUSIONS
Small biopsy diagnosis of primary pulmonary HCCC is challenging. A collection of mimics needed to be ruled out. Awareness of the key morphologic features of pulmonary HCCC combined with essential immunohistochemistry and molecular tests contributes to the correct diagnosis.
简介
透明细胞性汗腺瘤（HCCCs）是一种罕见的、低级别、恶性肿瘤。它们最常累及头颈部的小唾液腺。发生在不常见部位的 HCC 以及从小活检样本中检查，对大多数病理学家来说都是一个诊断挑战。
病例介绍
我们在此报告一例通过小活检诊断的原发性肺 HCC，并总结其组织学、免疫表型和分子特征，同时回顾 11 例先前报道的病例，以强调潜在的诊断陷阱。
结论
原发性肺 HCC 的小活检诊断具有挑战性。需要排除一系列类似的疾病。认识到肺 HCC 的关键形态特征，结合必要的免疫组织化学和分子检测，有助于正确诊断。
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