Department of Oncology, Anhui Wanbei Coal-Electricity Group General Hospital, Suzhou, China.
Department of Pathology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, China.
Diagn Pathol. 2022 Mar 27;17(1):35. doi: 10.1186/s13000-022-01216-5.
Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors. They most commonly involve the minor salivary glands of the head and neck. HCCC that occurs in uncommon locations and examining samples from small biopsy pose a diagnostic challenge for most pathologists.
We herein report a primary pulmonary HCCC diagnosed by small biopsy and summarize its histologic, immunophenotypic, and molecular features along with a review of 11 previously reported cases to emphasize the potential diagnostic pitfalls.
Small biopsy diagnosis of primary pulmonary HCCC is challenging. A collection of mimics needed to be ruled out. Awareness of the key morphologic features of pulmonary HCCC combined with essential immunohistochemistry and molecular tests contributes to the correct diagnosis.
透明细胞性汗腺瘤（HCCCs）是一种罕见的、低级别、恶性肿瘤。它们最常累及头颈部的小唾液腺。发生在不常见部位的 HCC 以及从小活检样本中检查，对大多数病理学家来说都是一个诊断挑战。
我们在此报告一例通过小活检诊断的原发性肺 HCC，并总结其组织学、免疫表型和分子特征，同时回顾 11 例先前报道的病例，以强调潜在的诊断陷阱。
原发性肺 HCC 的小活检诊断具有挑战性。需要排除一系列类似的疾病。认识到肺 HCC 的关键形态特征，结合必要的免疫组织化学和分子检测，有助于正确诊断。
