Dautzenberg B, Dautzenberg M-D
Service de pharmacologie, Pitié-Salpêtrière, AP-HP, 75013 Paris, France; Consultation de médecine, hôpital Marmottan, 75017 Paris, France; Consultation de tabacologie, institut Arthur-Vernes, 75006 Paris, France; Paris sans tabac, 14, avenue Bosquet, 75007 Paris, France.
Paris sans tabac, 14, avenue Bosquet, 75007 Paris, France.
Rev Mal Respir. 2019 Jan;36(1):82-103. doi: 10.1016/j.rmr.2018.10.010. Epub 2018 Nov 11.
The tobacco industry (TI) reports that heated tobacco reduces risk of tobacco use and will replace cigarettes. An analysis of the scientific literature was conducted in order to enlighten professionals and decision-makers.
After a Medline query in February 2018, a systematic analysis was conducted.
Of the 100 papers published in 2008-2018, 75 have authors affiliated or linked to TI. Emissions contain gases, droplets and solid particles, so are smokes. The main products are: THS2.2 (Iqos) which heats mini-cigarettes at 340°C, the THP1.0 (Glo) which heats at 240°C sticks delivering about half as much nicotine, Ploom which uses reconstituted tobacco microcapsules heated at 180°C. Under the experimental conditions, there is a reduction of toxic emissions and biological effects, but the expected risk reduction is not demonstrated. Symptoms related to passive smoking are described. The 4 epidemiological articles report that heated tobacco is used in 10 to 45% of cases by non-smokers and demonstrate the effectiveness of TI promotion campaigns. Thus, the THS2.2 is more a gateway to smoking (20%) than an exit door (11%); moreover, it is not expected risk reduction among the 69% who are mixed users.
While reducing emissions is documented, reducing the risk to the smoker who switches to heated-tobacco remains to be demonstrated. On the other hand, the worsening of the global tobacco risk related to the promotion of the products by the TI is anticipated, justifying that the authorities take the appropriate measures to control the promotion of heated tobacco.
烟草行业报告称，加热烟草可降低烟草使用风险，并将取代香烟。为了让专业人士和决策者了解情况，对科学文献进行了分析。
2018年2月在Medline上进行检索后，进行了系统分析。
在2008 - 2018年发表的100篇论文中，75篇的作者与烟草行业有关联或存在联系。其释放物包含气体、液滴和固体颗粒，因此属于烟雾。主要产品有：THS2.2（iQOS），在340°C加热迷你香烟；THP1.0（GLO），在240°C加热烟弹，释放的尼古丁量约为一半；Ploom，使用在180°C加热的再造烟草微胶囊。在实验条件下，有毒排放物和生物效应有所减少，但未证实能达到预期的风险降低效果。描述了与被动吸烟相关的症状。4篇流行病学文章报告称，10%至45%的非吸烟者使用加热烟草，并证明了烟草行业促销活动的有效性。因此，THS2.2更多是吸烟的入口（20%）而非出口（11%）；此外，在69%的混合使用者中未预期到风险降低。
虽然有文献记载加热烟草减少了排放，但转向使用加热烟草的吸烟者的风险降低情况仍有待证实。另一方面，预计烟草行业对这些产品的推广会使全球烟草风险加剧，这证明当局应采取适当措施控制加热烟草的推广。
