一株潜在的肺部病原体，从美国多位支气管扩张症患者中分离得到，包括首例囊性纤维化患者的临床疾病病例。
, a Potential Pulmonary Pathogen Isolated from Multiple Patients with Bronchiectasis in the United States, Including the First Case of Clinical Disease in a Patient with Cystic Fibrosis.
机构信息
Mycobacteria/Nocardia Research Laboratory, Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
Mycobacteria/Nocardia Research Laboratory, Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA
出版信息
J Clin Microbiol. 2019 Jan 30;57(2). doi: 10.1128/JCM.00906-18. Print 2019 Feb.
We characterize three respiratory isolates of the recently described species recovered in Texas, Louisiana, and Massachusetts, including the first case of disease in a patient with underlying cystic fibrosis. The three isolates had a 100% match to NE-TNMC-100812 by complete 16S rRNA, region V, and 65 gene sequencing. Core genomic comparisons between one isolate and the type strain revealed an average nucleotide identity of 99.8%. The isolates were susceptible to clarithromycin, amikacin, and rifabutin, while resistance was observed for tetracyclines, ciprofloxacin, and linezolid. should be added to the list of potential pulmonary pathogens, including in the setting of cystic fibrosis.
我们对在德克萨斯州、路易斯安那州和马萨诸塞州发现的三种最近描述的种的呼吸道分离株进行了特征描述，包括首例囊性纤维化患者的疾病病例。这三种分离株与 NE-TNMC-100812 通过完整的 16S rRNA、区域 V 和 65 个基因测序完全匹配。一个分离株与模式株之间的核心基因组比较显示平均核苷酸同一性为 99.8%。分离株对克拉霉素、阿米卡星和利福布汀敏感，而对四环素类、环丙沙星和利奈唑胺则有耐药性。应将其添加到潜在的肺部病原体列表中，包括囊性纤维化的情况。
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