Levy S, Kopersztych S, Musatti C C, Souen J S, Salvatore C A, Mendes N F
Am J Obstet Gynecol. 1978 Jan 15;130(2):160-4. doi: 10.1016/0002-9378(78)90360-5.
The thymus-dependent immunity of 42 patients with SCCC was evaluated by: delayed cutaneous reactions to ubiquitous antigens, DNCB sensitization, and lymphocyte response to PHA. In addition, T and B lymphocytes were detected in peripheral blood and in tumor sections, by adherence to E and HEAC. Depressed CMI was more intense in patients with disseminated disease, although a premature impairment of CMI was observed in some patients with initial-stage tumors. The absolute number of peripheral T lymphocytes showed association with both cutaneous reactions and PHA response. However, there appeared to be no significant correlation between the stage of the tumor and the pattern of adherence of E or HEAC to the biopsies.
通过以下方式评估了42例宫颈小细胞癌患者的胸腺依赖性免疫：对常见抗原的迟发性皮肤反应、二硝基氯苯致敏以及淋巴细胞对PHA的反应。此外，通过对E和HEAC的黏附，在外周血和肿瘤切片中检测了T和B淋巴细胞。尽管在一些早期肿瘤患者中观察到细胞介导免疫的过早损害，但在播散性疾病患者中，细胞介导免疫的抑制更为严重。外周T淋巴细胞的绝对数量与皮肤反应和PHA反应均相关。然而，肿瘤分期与活检中E或HEAC的黏附模式之间似乎没有显著相关性。
