College of Food Science, Southwest University, Chongqing, China.
College of Food Science, Southwest University, Chongqing, China.
Clin Breast Cancer. 2020 Aug;20(4):e469-e480. doi: 10.1016/j.clbc.2020.02.012. Epub 2020 Mar 6.
Epidemiologic studies focusing on the association between 1-carbon metabolism-related vitamins (ie, folate, vitamin B, vitamin B, vitamin B) and breast cancer risk have reported inconsistent findings. We conducted a systematic search of the reported data and performed a meta-analysis of prospective case-control and cohort studies to derive a more precise evaluation. The PubMed and EMBASE databases were searched to identify eligible studies. A total of 27 studies involving 49,707 cases and 1,274,060 individuals were included in the meta-analysis. The results indicated that a high intake of folate, vitamin B, and vitamin B might decrease the risk of breast cancer. The corresponding pooled relative risks (RRs) for the highest intake compared with the lowest were 0.93 (95% confidence interval [CI], 0.88-0.99; P = .018), 0.94 (95% CI, 0.89-1.00; P = .037) and 0.90 (95% CI, 0.82-0.99; P = .026). No significant association between vitamin B and breast cancer risk was found (RR, 0.99; 95% CI, 0.94-1.04; P = .604). Further study showed that folate and vitamin B might decrease the risk of estrogen receptor-negative (ER)/progesterone receptor-negative (PR) breast cancer but not ER/PR breast cancer. The dose-response meta-analysis indicated a significant linearity relationship between folate intake and a reduced risk of ER/PR breast cancer. An increment of folate intake (100 μg/d) corresponded to a 7% deceased risk of ER/PR breast cancer (RR, 0.93; 95% CI, 0.89-0.98; P = .007). In conclusion, a high intake of 1-carbon metabolism-related vitamins might contribute to the prevention of breast cancer, especially ER/PR breast cancer.
针对 1 碳代谢相关维生素（即叶酸、维生素 B、维生素 B、维生素 B）与乳腺癌风险之间的关联的流行病学研究报告结果并不一致。我们系统地检索了已发表的数据，并对前瞻性病例对照和队列研究进行了荟萃分析，以得出更准确的评估。我们检索了 PubMed 和 EMBASE 数据库以确定符合条件的研究。共有 27 项研究纳入了 49707 例病例和 1274060 名个体，纳入了荟萃分析。结果表明，高叶酸、维生素 B 和维生素 B 的摄入可能降低乳腺癌的风险。最高摄入量与最低摄入量相比的汇总相对风险（RR）分别为 0.93（95%置信区间[CI]，0.88-0.99；P =.018）、0.94（95% CI，0.89-1.00；P =.037）和 0.90（95% CI，0.82-0.99；P =.026）。维生素 B 与乳腺癌风险之间无显著关联（RR，0.99；95% CI，0.94-1.04；P =.604）。进一步的研究表明，叶酸和维生素 B 可能降低雌激素受体阴性（ER）/孕激素受体阴性（PR）乳腺癌的风险，但不降低 ER/PR 乳腺癌的风险。剂量-反应荟萃分析表明，叶酸摄入量与 ER/PR 乳腺癌风险降低之间存在显著的线性关系。叶酸摄入量增加（100μg/d）对应 ER/PR 乳腺癌风险降低 7%（RR，0.93；95% CI，0.89-0.98；P =.007）。总之，高摄入 1 碳代谢相关维生素可能有助于预防乳腺癌，尤其是 ER/PR 乳腺癌。
