Pregnancy complications and adverse outcomes in placental chorioangioma: a retrospective cohort analysis.

To measure the relative risk of pregnancy complications and adverse outcomes in women with placental chorioangioma, and postnatal developmental deficiencies in their offspring. We designed a retrospective cohort study using records from 140,387 pregnancies at our hospital between 1 January, 2008 and 1 July, 2017. Follow-up of children in the placental chorioangioma group was conducted by phone interview. Placental chorioangioma was diagnosed in 56 patients (incidence = 0.04%). Fifty-one cases were detected during routine prenatal ultrasound. Placental chorioangioma patients were at increased risk for fetal loss or induced abortion (RR = 9.93, 95% CI [4.66, 21.20]), preterm birth ( = 13, RR = 2.45, 95% CI [1.52, 3.95]), birth by cesarean section ( = 45, RR = 1.62, 95% CI [1.42, 1.84]), and polyhydramnios ( = 9, RR = 9.98, 95% CI [5.48, 18.18]), but not fetal distress ( = 5, RR = 0.49, 95% CI [0.22, 1.15]) or preeclampsia ( = 5, RR = 1.61, 95% CI [0.70, 3.73]), although there was an increased risk for preeclampsia after controlling for preterm birth ( = 3, RR = 3.6, 95% CI [1.33, 9.74]). No developmental complications were reported in offspring. Placental chorioangioma increases the risk of fetal demise, pregnancy complications and adverse outcomes. In cases with mild complications or when early cesarean termination of pregnancy is feasible, the prognosis is excellent.