庆大霉素治疗实验性阴沟肠杆菌心内膜炎。体外杀菌率的预测价值
[Experimental Enterobacter cloacae endocarditis treated with gentamicin. Predictive value of the in vitro bactericidal rate].
作者信息
Potel G, Caillon J, Bugnon D, Lecomte P, Drugeon H B, Baron D
机构信息
Laboratoire d'Antibiologie, Faculté de Médecine, 1, Nantes.
出版信息
Pathol Biol (Paris). 1988 May;36(5):536-9.
PMID:3043353
Abstract
The predictive value of in vitro time-kill curve was tested on an Enterobacter cloacae endocarditis experimental model. The antibiotic studied was gentamicin. Despite a similar MIC, 2 Enterobacter cloacae strains exhibited very different time-kill curves in vitro. This difference was found being predictive of efficacy on the in vivo model, 24 hours after a single injection of gentamicin.
摘要
在阴沟肠杆菌心内膜炎实验模型上测试了体外时间杀菌曲线的预测价值。所研究的抗生素是庆大霉素。尽管最低抑菌浓度（MIC）相似，但2株阴沟肠杆菌菌株在体外表现出非常不同的时间杀菌曲线。发现这种差异可预测在单次注射庆大霉素24小时后体内模型的疗效。
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