Gualtieri C T, Evans R W
Biological Sciences Research Center, University of North Carolina, Chapel Hill.
Percept Mot Skills. 1988 Jun;66(3):763-9. doi: 10.2466/pms.1988.66.3.763.
The effects of the tricyclic antidepressant imipramine were evaluated in a study of 9 children with Attention Deficit-Hyperactivity Disorder. The study was double-blind, placebo-controlled, with three drug conditions, low, medium, and high doses. The focus was on neuropsychological drug effects. Imipramine exerted negative dose-response effects on motor performance (motor speed, motor pursuit), while it improved hyperactive behavior and attention and raised the heart rate slightly.
