Kirchhof Mark G, Landells Ian, Lynde Chuck W, Gooderham Melinda J, Hong Chih-Ho
J Cutan Med Surg. 2018 Nov/Dec;22(1_suppl):6S-9S. doi: 10.1177/1203475418803626.
Atopic dermatitis (AD) is a chronic, relapsing, and remitting inflammatory skin disease whose onset typically occurs early in life. AD pathophysiology includes genetic, immune, and environmental factors contributing to chronic inflammation. A rapidly evolving understanding of the pathogenesis of AD has led to the development of several treatment options for AD in adults, including topicals, phototherapy, and systemic therapies. Here, we provide a concise summary of AD pathophysiology with a focus on implications for systemic therapy.
特应性皮炎（AD）是一种慢性、复发性、缓解性炎症性皮肤病，其发病通常始于生命早期。AD的病理生理学包括导致慢性炎症的遗传、免疫和环境因素。对AD发病机制的快速深入了解已促使开发出多种针对成人AD的治疗方案，包括局部用药、光疗和全身治疗。在此，我们简要总结AD的病理生理学，重点关注其对全身治疗的影响。
