Opt Lett. 2018 Nov 15;43(22):5555-5558. doi: 10.1364/OL.43.005555.
To improve the imaging performance of optical projection tomography (OPT) in live samples, we have explored a parallelized implementation of semi-confocal line illumination and detection to discriminate against scattered photons. Slice-illuminated OPT (sl-OPT) improves reconstruction quality in scattering samples by reducing interpixel crosstalk at the cost of increased acquisition time. For in vivo imaging, this can be ameliorated through the use of compressed sensing on angularly undersampled OPT data sets. Here, we demonstrate sl-OPT applied to 3D imaging of bead phantoms and live adult zebrafish.
为了提高光学投影层析成像（OPT）在活体样本中的成像性能，我们探索了一种并行实现的半共焦线照明和检测方法，以区分散射光子。切片照明 OPT（sl-OPT）通过减少像素间串扰来提高散射样本中的重建质量，但代价是增加采集时间。对于体内成像，可以通过对角度欠采样的 OPT 数据集应用压缩感知来改善。在这里，我们展示了 sl-OPT 在珠状幻影和活体成年斑马鱼的 3D 成像中的应用。
