Nyerges G, Mészner Z
1st Chair of Pediatrics, Postgraduate Medical School, Budapest, Hungary.
Am J Med. 1988 Aug 29;85(2A):94-5.
In Hungary since 1981, 98 immunocompromised children have been treated with intravenous acyclovir for varicella zoster virus infections. They were treated in an open study or a double-blind study. Results of both are discussed briefly. Overall, five of 74 patients with varicella died, whereas all 24 patients with herpes zoster recovered. Treatment failures occurred in patients in whom treatment started late and in those with severe lymphocytopenia. In some children, varicella zoster virus-specific antibodies failed to develop by the end of treatment, and a proportion of these suffered recurrent episodes of varicella.
自1981年以来，匈牙利有98名免疫功能低下的儿童接受了静脉注射阿昔洛韦治疗水痘带状疱疹病毒感染。他们参与了一项开放性研究或双盲研究。两项研究的结果将简要讨论。总体而言，74名水痘患者中有5人死亡，而24名带状疱疹患者全部康复。治疗开始较晚的患者和严重淋巴细胞减少的患者出现了治疗失败的情况。在一些儿童中，治疗结束时水痘带状疱疹病毒特异性抗体未能产生，其中一部分儿童出现了水痘复发。
