Instituto Mexicano del Seguro Social, Departamento de Epidemiología, Unidad de Medicina Familiar No. 19, Av. Javier Mina 301, Col. Centro, CP 28000 Colima, Mexico.
Programa de Doctorado en Ciencias Médicas, Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Col. Las Víboras, CP 28040 Colima, Mexico.
Int J Environ Res Public Health. 2018 Nov 14;15(11):2552. doi: 10.3390/ijerph15112552.
We aimed to screen for depressive mood experienced during acute chikungunya (CHIKV) infection, and to evaluate the association of several exposures with the risk of depressive symptoms. A cross-sectional analysis of a multicenter cohort study took place and data from 354 adult individuals with confirmed CHIKV infection were analyzed. Participants were recruited in primary health care settings and the Patient Health Questionnaire-2 (PHQ-2) was used. Prevalence odds ratios (OR) and 95% confidence intervals (CIs) estimated by means of logistic models were used. Depressive mood (PHQ-2 score 3 or higher) was reported by 44.1% of individuals. Subjects with articular effusion (OR = 3.37, 95% CI 1.77⁻8.11), gastrointestinal manifestations (diarrhea, vomiting or abdominal pain, OR = 1.97, 95 CI 1.21⁻3.19), and higher length of severe arthralgia (reference ≤ 14 days: 15⁻30 days, OR = 3.38, 95% CI 1.78⁻6.41; ≥ 30 days, OR = 1.69, 95% CI 0.95⁻3.01) were more likely to self-report depressive mood. Increasing age (≥ 40 years old, OR = 0.55, 95% CI 0.31⁻0.95) and rash (OR = 0.54, 95% CI 0.30⁻0.98) were associated with a decreased risk of depressive mood. Depressive mood seemed to be a frequent event among analyzed individuals, and markers associated with its risk were identified.
我们旨在筛查急性基孔肯雅热（CHIKV）感染期间经历的抑郁情绪，并评估几种暴露因素与抑郁症状风险的关系。进行了一项多中心队列研究的横断面分析，分析了 354 名确诊 CHIKV 感染的成年个体的数据。参与者在基层医疗保健环境中招募，使用患者健康问卷-2（PHQ-2）进行评估。使用逻辑模型估计患病率比值比（OR）和 95％置信区间（CI）。44.1％的个体报告有抑郁情绪（PHQ-2 评分 3 或更高）。有关节积液（OR=3.37，95％CI 1.77⁻8.11）、胃肠道表现（腹泻、呕吐或腹痛，OR=1.97，95％CI 1.21⁻3.19）和较长时间严重关节痛（参考≤14 天：15⁻30 天，OR=3.38，95％CI 1.78⁻6.41；≥30 天，OR=1.69，95％CI 0.95⁻3.01）的患者更有可能自我报告抑郁情绪。年龄较大（≥40 岁，OR=0.55，95％CI 0.31⁻0.95）和皮疹（OR=0.54，95％CI 0.30⁻0.98）与抑郁情绪风险降低相关。抑郁情绪似乎是分析人群中常见的事件，并且确定了与风险相关的标志物。
