Department of Pediatric Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1665 Kongjiang RD, Shanghai, 200092, China.
Clinical Research Unit, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
J Neurooncol. 2019 Feb;141(3):567-573. doi: 10.1007/s11060-018-03004-y. Epub 2018 Nov 15.
The compound, 5-aminolevulinic acid (5-ALA) is approved for fluorescence-guided resections of malignant gliomas in Europe and other countries for use in adults, but not for children. The application of 5-ALA in children remains an off-label use. Several case reports on fluorescence-guided surgery use in children have been published, yet no prospective study has been conducted. Here we systematically review the reported studies and discuss the usefulness, application, and safety of 5-ALA use in resection of pediatric brain tumors.
该化合物，5-氨基酮戊酸（5-ALA）在欧洲和其他国家被批准用于成人恶性胶质瘤的荧光引导切除，但不适用于儿童。5-ALA 在儿童中的应用仍然是一种超适应证使用。已经发表了一些关于儿童荧光引导手术应用的病例报告，但尚未进行前瞻性研究。在这里，我们系统地回顾了已报道的研究，并讨论了 5-ALA 在切除小儿脑瘤中的应用的有用性、适用性和安全性。
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