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基于声时编码外源性声波刺激的眼压远程光学生物监测

Intraocular pressure remote photonic biomonitoring based on temporally encoded external sound wave stimulation.

机构信息

Bar-Ilan University, Faculty of Engineering and the Nanotechnology Center, Ramat-Gan, Israel.

Tel-Aviv University, Goldshleger Eye Research Institute, Tel Aviv, Israel.

出版信息

J Biomed Opt. 2018 Nov;23(11):1-9. doi: 10.1117/1.JBO.23.11.117001.

Abstract

Continuous noninvasive measurement of intraocular pressure (IOP) is an important tool in the evaluation process for glaucoma. We present a methodology enabling high-precision, noncontact, reproducible, and continuous monitoring of IOP based on the value of the damping factor of transitional oscillations obtained at the surface of the eye after terminating its stimulation by a sound wave. The proposed configuration includes projection of a laser beam and usage of a fast camera for analyzing the temporal-spatial variations of the speckle patterns backscattered from the iris or the sclera following the above-mentioned sound waves external stimulation. The methodology was tested on an artificial eye and a carp fish eye under varying pressure as well as on human eyes.

摘要

连续无创测量眼内压(IOP)是青光眼评估过程中的重要工具。我们提出了一种基于眼睛表面在受到声波刺激后过渡振荡阻尼因子值的高精度、非接触、可重复和连续监测 IOP 的方法。所提出的配置包括激光束的投影和使用高速相机分析在上述声波外部刺激后从虹膜或巩膜反向散射的散斑图案的时空间变化。该方法在人造眼球和鲤鱼眼球以及人类眼球上进行了测试,压力可变化。

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