Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; University of Basel, Faculty of Sciences, Basel, Switzerland.
Cell. 2018 Nov 15;175(5):1179-1181. doi: 10.1016/j.cell.2018.10.046.
In this issue, Kazachenka, Bertozzi, and colleagues identify elements in the mouse genome with epigenetic variability between littermates, a phenomenon linked to transmission of phenotypes over generations. This addresses two questions that remained unanswered despite intense speculation: how prevalent are these alleles, and what is their effect, within and across generations?
在本期中，Kazachenka、Bertozzi 和同事们确定了在同窝仔鼠之间具有表观遗传可变性的小鼠基因组中的元素，这种现象与表型在几代中的传递有关。这解决了两个尽管存在激烈猜测但仍未得到解答的问题：这些等位基因在代内和代际中有多普遍，它们的影响是什么？
