Sidra Medicine, Doha, Qatar.
Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, München, Germany.
Chem Senses. 2019 Jan 1;44(1):7-9. doi: 10.1093/chemse/bjy074.
Aiming to unravel interspecific differences in olfactory preferences, we performed comparative studies of odor valence in flies, mice, and humans. Our analysis suggests a model where flies and mice share similar olfactory preferences, but neither species share odor preferences with humans. This model contrasts with a previous study by Mandairon et al., which suggested that the olfactory preferences of mice and humans are similar. A probabilistic examination revealed that underpowered studies can result in spurious significant correlations, which can account for the differences between both studies. Future analyses aimed at dissecting the olfactory preferences across species need to test large numbers of odorants to stress-test the model proposed here and identify robust associations.
为了揭示种间嗅觉偏好的差异，我们对果蝇、小鼠和人类的气味效价进行了比较研究。我们的分析提出了一个模型，即果蝇和小鼠具有相似的嗅觉偏好，但它们都与人类的嗅觉偏好不同。这一模型与 Mandairon 等人之前的研究相反，后者表明小鼠和人类的嗅觉偏好相似。概率检验表明，研究力度不足可能导致虚假的显著相关性，这可以解释两项研究之间的差异。未来旨在剖析跨物种嗅觉偏好的分析需要测试大量的气味，以检验这里提出的模型并确定稳健的关联。
