Max Planck Institute for Chemical Ecology, Hans-Knöll Strasse 8, 07745 Jena, Germany.
Cell Rep. 2012 Apr 19;1(4):392-9. doi: 10.1016/j.celrep.2012.03.002. Epub 2012 Apr 20.
Brains have to decide whether and how to respond to detected stimuli based on complex sensory input. The vinegar fly Drosophila melanogaster evaluates food sources based on olfactory cues. Here, we performed a behavioral screen using the vinegar fly and established the innate valence of 110 odorants. Our analysis of neuronal activation patterns evoked by attractive and aversive odorants suggests that even though the identity of odorants is coded by the set of activated receptors, the main representation of odorant valence is formed at the output level of the antennal lobe. The topographic clustering within the antennal lobe of valence-specific output neurons resembles a corresponding domain in the olfactory bulb of mice. The basal anatomical structure of the olfactory circuit between insects and vertebrates is known to be similar; our study suggests that the representation of odorant valence is as well.
大脑必须基于复杂的感官输入来决定是否以及如何对检测到的刺激做出反应。黑腹果蝇(Drosophila melanogaster)根据嗅觉线索来评估食物来源。在这里，我们使用黑腹果蝇进行了行为筛选，并确定了 110 种气味的先天效价。我们对由有吸引力和厌恶的气味引起的神经元激活模式的分析表明，尽管气味的身份是由激活的受体集编码的，但气味效价的主要表示是在触角叶的输出水平形成的。在触角叶中与效价特异性输出神经元的拓扑聚类类似于小鼠嗅球中的相应域。昆虫和脊椎动物之间的嗅觉回路的基本解剖结构已知是相似的;我们的研究表明，气味效价的表示也是如此。
