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Biomolecules. 2018 Nov 15;8(4):148. doi: 10.3390/biom8040148.
The dual-family peptidylprolyl isomerases (immunophilins) represent a naturally occurring chimera of the classical FK506-binding protein (FKBP) and cyclophilin (CYN), connected by a flexible linker. They are found exclusively in monocellular organisms. The modular builds of these molecules represent two distinct types: CYN-(linker)-FKBP and FKBP-3TPR (tetratricopeptide repeat)-CYN. Abbreviated respectively as CFBP and FCBP, the two classes also exhibit distinct organism preference, the CFBP being found in prokaryotes, and the FCBP in eukaryotes. This review summarizes the mystery of these unique class of prolyl isomerases, focusing on their host organisms, potential physiological role, and likely routes of evolution.
双家族肽基脯氨酰顺反异构酶（免疫亲和素）是经典 FK506 结合蛋白（FKBP）和亲环素（CYN）的自然嵌合体，通过一个柔性接头连接在一起。它们仅存在于单细胞生物中。这些分子的模块构建代表了两种截然不同的类型：CYN-（接头）-FKBP 和 FKBP-3TPR（四肽重复）-CYN。分别缩写为 CFBP 和 FCBP，这两个类也表现出不同的宿主偏好，CFBP 存在于原核生物中，而 FCBP 存在于真核生物中。本综述总结了这些独特的脯氨酰异构酶类的奥秘，重点关注它们的宿主生物、潜在的生理作用以及可能的进化途径。
