一种评估脑多巴胺代谢的生物化学新方法。
A new approach to biochemical evaluation of brain dopamine metabolism.
作者信息
Kopin I J, White J H, Bankiewicz K
机构信息
National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.
出版信息
Cell Mol Neurobiol. 1988 Jun;8(2):171-9. doi: 10.1007/BF00711243.
Abstract
- Dopaminergic neurotransmission in brain is receiving increased attention because of its known involvement in Parkinson's disease and new methods for the treatment of this disorder and because of hypotheses relating several psychiatric disorders to abnormalities in brain dopaminergic systems. 2. Chemical assessment of brain dopamine metabolism has been attempted by measuring levels of its major metabolite, homovanillic acid (HVA), in cerebrospinal fluid, plasma, or urine. Because HVA is derived in part from dopamine formed in noradrenergic neurons, plasma levels and urinary excretion rates of HVA do not adequately reflect solely metabolism of brain dopamine. 3. Using debrisoquin, the peripheral contributions of HVA to plasma or urinary HVA can be diminished, but the extent of residual HVA formation in noradrenergic neurons is unknown. By measuring the levels of methoxy-hydroxyphenylglycol (MHPG) in plasma or of urinary norepinephrine metabolites (total MHPG in monkeys; the sum of total MHPG and vanillyl mandelic acid (VMA) in humans) along with HVA, it is possible to estimate the degree of impairment by debrisoquin of HVA formation from noradrenergic neuronal dopamine and thereby better assess brain dopamine metabolism. 4. This method was applied to a monkey before and after destruction of the nigrostriatal pathway by the administration of MPTP.
摘要
- 由于多巴胺能神经传递已知与帕金森病以及该疾病的新治疗方法有关，还因为有假说将几种精神疾病与脑多巴胺能系统异常联系起来，所以它在大脑中的作用正受到越来越多的关注。2. 人们曾试图通过测量脑脊液、血浆或尿液中多巴胺的主要代谢产物高香草酸（HVA）的水平来对脑多巴胺代谢进行化学评估。由于HVA部分源自去甲肾上腺素能神经元中形成的多巴胺，所以HVA的血浆水平和尿排泄率并不能充分反映脑多巴胺的单独代谢情况。3. 使用降压嗪可以减少HVA对血浆或尿液HVA的外周贡献，但去甲肾上腺素能神经元中残留的HVA形成程度尚不清楚。通过测量血浆中甲氧基 - 羟基苯乙二醇（MHPG）的水平或尿液中去甲肾上腺素代谢产物（猴子中的总MHPG；人类中总MHPG和香草扁桃酸（VMA）的总和）以及HVA，可以估计降压嗪对去甲肾上腺素能神经元多巴胺形成HVA的损害程度，从而更好地评估脑多巴胺代谢。4. 该方法应用于一只通过给予MPTP破坏黑质纹状体通路前后的猴子。
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