在给予异喹胍期间，MPTP诱导的猴子帕金森病对高香草酸（HVA）和3-甲氧基-4-羟基苯乙二醇（MHPG）尿排泄的影响。

Effect of MPTP-induced parkinsonism in monkeys on the urinary excretion of HVA and MHPG during debrisoquin administration.

作者信息

Kopin I J, Bankiewicz K, Harvey-White J

机构信息

National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.

出版信息

Life Sci. 1988;43(2):133-41. doi: 10.1016/0024-3205(88)90290-1.

DOI:10.1016/0024-3205(88)90290-1

PMID:3260652

Abstract

During debrisoquin administration to three monkeys there were significant reductions in excretion rates of HVA, the major dopamine metabolite, and MHPG, the major norepinephrine metabolite. Excretion rates of HVA were highly correlated to those of MHPG. The regression line relating HVA and MHPG excretion suggests that a portion of HVA (about 25%) is derived from a source independent of norepinephrine metabolites. There was a striking reduction of this portion of HVA excretion after MPTP-induced destruction of dopaminergic nigrostriatal neurons. These results support the view that the rate of HVA formation in brain dopaminergic neurons can be estimated from the relationship of urinary excretion rates of HVA and MHPG before and during debrisoquin treatment.

摘要

在给三只猴子服用异喹胍期间，主要多巴胺代谢产物高香草酸（HVA）和主要去甲肾上腺素代谢产物3-甲氧基-4-羟基苯乙二醇（MHPG）的排泄率显著降低。HVA的排泄率与MHPG的排泄率高度相关。HVA和MHPG排泄之间的回归线表明，一部分HVA（约25%）来源于独立于去甲肾上腺素代谢产物的来源。在MPTP诱导的多巴胺能黑质纹状体神经元破坏后，这部分HVA排泄显著减少。这些结果支持这样一种观点，即可以根据异喹胍治疗前后尿液中HVA和MHPG排泄率的关系来估计脑多巴胺能神经元中HVA的形成速率。