Department of Urology, Emory University, Atlanta, GA.
Department of Urology, Emory University, Atlanta, GA; Department of Microbiology and Immunology, Emory University, Atlanta, GA.
Urol Oncol. 2019 Aug;37(8):543-555. doi: 10.1016/j.urolonc.2018.10.011. Epub 2018 Nov 13.
Immunotherapy-particularly immune checkpoint blockade-has seen great success in many tumor types. However, checkpoint-based therapies have not demonstrated high levels of success in prostate cancer, and there is much to be learned from both the successes and failures of these treatments. Here we review the evidence that composition of infiltrating immune cells in the tumor microenvironment is fundamental to the response to immunotherapy. Additionally, we discuss the emerging idea that the organization of these immune cells may also be crucial to this response. In prostate cancer, the composition and organization of the tumor immune microenvironment are preeminent topics of discussion and areas of important future investigation.
免疫疗法——尤其是免疫检查点阻断——在许多肿瘤类型中取得了巨大成功。然而，基于检查点的疗法在前列腺癌中并未显示出很高的成功率，因此从这些治疗的成功和失败中可以吸取很多经验教训。在这里，我们回顾了肿瘤微环境中浸润免疫细胞的组成对于免疫治疗反应至关重要的证据。此外，我们还讨论了一个新的观点，即这些免疫细胞的组织也可能对这种反应至关重要。在前列腺癌中，肿瘤免疫微环境的组成和组织是讨论的首要主题，也是未来重要的研究领域。
