Milburn H J, Grundy J E, du Bois R M, Prentice H G, Griffiths P D
Department of Thoracic Medicine, Royal Free Hospital, Hampstead, London, U.K.
Clin Exp Immunol. 1988 May;72(2):309-14.
We investigated 20 bone marrow transplant recipients with pneumonitis using bronchoalveolar lavage (BAL) to assess the humoral immune response in the lung. We measured the levels of total IgG, IgM and IgA in bronchoalveolar lavage fluid and serum, and albumin measurements were used to correct for simple diffusion of immunoglobulins from serum into the lung. We found evidence for the local production of immunoglobulins G, M and A in 15 patients. This was independent of the cause of the pneumonitis. We also found that, although seven patients who recovered from their pulmonary problem had evidence of considerable local production of immunoglobulin, eight patients who died were also producing immunoglobulins in the lung. Death due to pneumonitis in BMT recipients cannot, therefore, be ascribed to a failure of the local humoral immune response.
我们对20例患有肺炎的骨髓移植受者进行了研究，采用支气管肺泡灌洗（BAL）来评估肺部的体液免疫反应。我们测定了支气管肺泡灌洗液和血清中总IgG、IgM和IgA的水平，并通过白蛋白测定来校正免疫球蛋白从血清向肺的单纯扩散。我们发现15例患者有免疫球蛋白G、M和A在局部产生的证据。这与肺炎的病因无关。我们还发现，虽然7例从肺部问题中康复的患者有大量免疫球蛋白在局部产生的证据，但8例死亡患者的肺部也在产生免疫球蛋白。因此，骨髓移植受者因肺炎死亡不能归因于局部体液免疫反应的失败。
